TAF5, TATA-box binding protein associated factor 5

TAF5, TATA-box binding protein associated factor 5

• Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

• Gene Synonyms (transcription initiation factor TFIID subunit 5, TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa, TATA box binding protein (TBP)-associated factor 2D, TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD, transcription initiation factor TFIID 100 kD subunit, transcription initiation factor TFIID 100 kDa subunit, TAF(II)100, TAF2D, TAFII-100, TAFII100,)
• NCBI Gene ID: 6877
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15542
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TATA-box binding protein associated factor 5 interacts with:

• anaphase promoting complex subunit 10
  autophagy related 16 like 1
  cell division cycle 16
  cleavage and polyadenylation specific factor 1
  cullin 3
  flotillin 1
  glycogen synthase kinase 3 beta
  H3 clustered histone 1
  H3.4 histone
  H4 clustered histone 1
  kinesin associated protein 3
  kinesin family member 21B
  malonyl-CoA-acyl carrier protein transacylase
  mediator complex subunit 26
  microtubule associated serine/threonine kinase 3
  nuclear receptor subfamily 2 group C member 2
  septin 6
  SPT3 homolog, SAGA and STAGA complex component
  structural maintenance of chromosomes 3
  TATA-box binding protein
  TATA-box binding protein associated factor 1 like
  TATA-box binding protein associated factor 10
  TATA-box binding protein associated factor 11
  TATA-box binding protein associated factor 12
  TATA-box binding protein associated factor 13
  TATA-box binding protein associated factor 15
  TATA-box binding protein associated factor 3
  TATA-box binding protein associated factor 6
  TATA-box binding protein associated factor 7
  TATA-box binding protein associated factor 7 like
  TATA-box binding protein associated factor 8
  TATA-box binding protein associated factor 9
  TATA-box binding protein associated factor 9b
  TATA-box binding protein like 1
  transformation/transcription domain associated protein
  tumor protein p53
  ubiquitin conjugating enzyme E2 I
  WD repeat domain 76

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.