TAPBP, TAP binding protein

TAPBP, TAP binding protein

• This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tapasin, NGS-17, TAP binding protein (tapasin), TAP-associated protein, NGS17, TAPA, TPN, TPSN,)
• NCBI Gene ID: 6892
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0A0MSV9
  UNIPROT ID#>>A0A024RCT1
  UNIPROT ID#>>O15533
  UNIPROT ID#>>A0A0A0MT98
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TAP binding protein interacts with:

• autophagy related 16 like 1
  COPI coat complex subunit gamma 1
  COPI coat complex subunit gamma 2
  H4 clustered histone 1
  limb development membrane protein 1 like
  nuclear RNA export factor 1
  ubiquitin C

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.