TCF7, transcription factor 7

TCF7, transcription factor 7

• This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]

• Gene Synonyms (transcription factor 7, T-cell-factor-7, T-cell-specific transcription factor 1, transcription factor 7 (T-cell specific, HMG-box), TCF-1,)
• NCBI Gene ID: 6932
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KQ75
  UNIPROT ID#>>P36402
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transcription factor 7 interacts with:

• cullin 4A
  DAZ associated protein 2
  praja ring finger ubiquitin ligase 2
  SS18L1 subunit of BAF chromatin remodeling complex
  ubiquitin C-terminal hydrolase L5
  zinc finger MIZ-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.