THPO, thrombopoietin

THPO, thrombopoietin

• Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]

• Gene Synonyms (thrombopoietin, MPL ligand, c-mpl ligand, megakaryocyte colony-stimulating factor, megakaryocyte growth and development factor, megakaryocyte stimulating factor, myeloproliferative leukemia virus oncogene ligand, prepro-thrombopoietin, MGDF, MKCSF, ML, MPLLG, THCYT1, TPO,)
• NCBI Gene ID: 7066
• Species: Homo sapiens (Human)
• UNIPROT ID#>>F8W6L1
  UNIPROT ID#>>Q5FBX8
  UNIPROT ID#>>P40225
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

thrombopoietin interacts with:

• aph-1 homolog A, gamma-secretase subunit
  NUMB like endocytic adaptor protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.