ZIC2, Zic family member 2

ZIC2, Zic family member 2

• This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2016]

• Gene Synonyms (zinc finger protein ZIC 2, Zic family member 2 (odd-paired homolog, Drosophila), Zinc finger protein of the cerebellum 2, HPE5,)
• NCBI Gene ID: 7546
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95409
  UNIPROT ID#>>A0A024RDY6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Zic family member 2 interacts with:

• adenosylhomocysteinase like 2
  egl-9 family hypoxia inducible factor 3
  F-box and WD repeat domain containing 11
  N-acetylglucosamine kinase
  Nanog homeobox
  ring finger protein 180
  TEA domain transcription factor 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.