TUSC3, tumor suppressor candidate 3

TUSC3, tumor suppressor candidate 3

• This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]

• Gene Synonyms (tumor suppressor candidate 3, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3, magnesium uptake/transporter TUSC3, mental retardation, non-syndromic, autosomal recessive, 22, oligosaccharyl transferase subunit TUSC3, oligosaccharyltransferase 3 homolog A, putative prostate cancer tumor suppressor, D8S1992, M33, MRT22, MRT7, MagT2, N33, OST3A, SLC58A2,)
• NCBI Gene ID: 7991
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13454
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tumor suppressor candidate 3 interacts with:

• 5-hydroxytryptamine receptor 3C
  family with sequence similarity 122B
  F-box protein 6
  lin-54 DREAM MuvB core complex component
  mucolipin 3
  NDRG family member 3
  ring finger protein 185
  SLC9A3 regulator 2
  sodium voltage-gated channel beta subunit 3
  spectrin repeat containing nuclear envelope family member 4
  uroplakin 1A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.