CTC1, CST telomere replication complex component 1

CTC1, CST telomere replication complex component 1

• This gene encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]

• Gene Synonyms (CST complex subunit CTC1, CST telomere maintenance complex component 1, CTS telomere maintenance complex component 1, HBV DNAPTP1-transactivated protein B, alpha accessory factor 132, conserved telomere capping protein 1, AAF-132, AAF132, C17orf68, CRMCC, tmp494178,)
• NCBI Gene ID: 80169
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q2NKJ3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CST telomere replication complex component 1 interacts with:

• KH RNA binding domain containing, signal transduction associated 2
  leucine zipper tumor suppressor 2
  protein tyrosine phosphatase, non-receptor type 23
  shieldin complex subunit 1
  STN1, CST complex subunit
  TEN1 subunit of CST complex

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