CCM2, CCM2 scaffold protein

CCM2, CCM2 scaffold protein

• This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]

• Gene Synonyms (cerebral cavernous malformations 2 protein, CCM2 scaffolding protein, cerebral cavernous malformation 2, malcavernin, osmosensing scaffold for MEKK3, C7orf22, OSM, PP10187,)
• NCBI Gene ID: 83605
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BSQ5
  UNIPROT ID#>>B7Z8D5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CCM2 scaffold protein interacts with:

• twist family bHLH transcription factor 2
  ubiquitin protein ligase E3D
  V-set and transmembrane domain containing 2 like

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