TMEM107, transmembrane protein 107

TMEM107, transmembrane protein 107

• This gene encodes a transmembrane protein and component of the primary cilia transition zone. The encoded protein regulates ciliogenesis and ciliary protein composition. Human fibroblasts expressing a mutant allele of this gene exhibit reduced numbers of cilia, altered cilia length, and impaired sonic hedgehog signaling. In human patients, different mutations in this gene cause different ciliopathies, including Meckel-Gruber syndrome and orofaciodigital syndrome. [provided by RefSeq, May 2017]

• Gene Synonyms (transmembrane protein 107, GRVS638, JBTS29, MKS13, PRO1268,)
• NCBI Gene ID: 84314
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6UX40
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transmembrane protein 107 interacts with:

• ATPase phospholipid transporting 11C
  family with sequence similarity 209 member A
  family with sequence similarity 210 member B
  glutathione peroxidase 8 (putative)
  LHFPL tetraspan subfamily member 5
  pecanex 3
  solute carrier family 10 member 6
  synaptotagmin 2
  transmembrane protein 106A
  transmembrane protein 139
  transmembrane protein 179B
  transmembrane protein 31
  transmembrane protein 52B
  transmembrane protein 80
  transmembrane protein 86B
  vacuolar ATPase assembly factor VMA21

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.