TMEM185A, transmembrane protein 185A

TMEM185A, transmembrane protein 185A

• The protein encoded by this gene is predicted to be a transmembrane protein. This gene is best known for localizing to the CpG island of the fragile site FRAXF. The 5' untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Aug 2013]

• Gene Synonyms (transmembrane protein 185A, family with sequence similarity 11, member A, fragile site, folic acid type, rare, fra(X)(q28) F, CXorf13, FAM11A, FRAXF, ee3,)
• NCBI Gene ID: 84548
• Species: Homo sapiens (Human)
• UNIPROT ID#>>E7EMM1
  UNIPROT ID#>>B7Z4G6
  UNIPROT ID#>>Q8NFB2
  UNIPROT ID#>>Q8TCB3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transmembrane protein 185A interacts with:

• ATPase H+ transporting V0 subunit d2
  ATPase phospholipid transporting 11C
  CD109 molecule
  copine 2
  copine 8
  cyclin Y
  cyclin Y like 1
  G protein regulated inducer of neurite outgrowth 1
  glutamate rich 5
  receptor accessory protein 6
  small VCP interacting protein
  ubiquitin domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.