HDGFL2, HDGF like 2

HDGFL2, HDGF like 2

• This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

• Gene Synonyms (hepatoma-derived growth factor-related protein 2, HDGF-related protein 2, HDGF-2, HDGF2, HDGFRP2, HRP-2, HRP2,)
• NCBI Gene ID: 84717
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7Z4V5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

HDGF like 2 interacts with:

• chromosome alignment maintaining phosphoprotein 1
  dual specificity phosphatase 19
  H3 clustered histone 14
  leucine rich repeat kinase 2
  membrane magnesium transporter 1
  pre T cell antigen receptor alpha
  pyrin and HIN domain family member 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.