DDX3Y, DEAD-box helicase 3 Y-linked

DDX3Y, DEAD-box helicase 3 Y-linked

• The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

• Gene Synonyms (ATP-dependent RNA helicase DDX3Y, DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked, DEAD box protein 3, Y-chromosomal, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, Y chromosome, DBY,)
• NCBI Gene ID: 8653
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15523
  UNIPROT ID#>>A0A024R9A4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DEAD-box helicase 3 Y-linked interacts with:

• cyclin B2
  F-box protein 6
  HEXIM P-TEFb complex subunit 1
  immunoglobulin superfamily member 8
  La ribonucleoprotein 7, transcriptional regulator
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 3
  NudC domain containing 2
  pleckstrin homology domain containing A4
  POC1 centriolar protein A
  protection of telomeres 1
  RecQ like helicase 4
  RIO kinase 1
  RNA polymerase II associated protein 1
  Sin3A associated protein 25
  tripartite motif containing 28
  WW domain containing oxidoreductase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.