B4GALT4, beta-1,4-galactosyltransferase 4

B4GALT4, beta-1,4-galactosyltransferase 4

• This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (beta-1,4-galactosyltransferase 4, N-acetyllactosamine synthase, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 4, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4, beta-1,4-GalTase 4, beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 4, lactotriaosylceramide beta-1,4-galactosyltransferase, nal synthase, B4Gal-T4, beta4Gal-T4,)
• NCBI Gene ID: 8702
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B2RAZ5
  UNIPROT ID#>>O60513
  UNIPROT ID#>>B3KM35
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

beta-1,4-galactosyltransferase 4 interacts with:

• claudin domain containing 1
  COBW domain containing 3
  N-glycanase 1
  nuclear RNA export factor 1
  proteasome (prosome, macropain) subunit, beta type 5
  striatin 3
  stromal cell derived factor 2 like 1
  tubulin, gamma 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.