PHOX2B, paired like homeobox 2B

PHOX2B, paired like homeobox 2B

• The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]

• Gene Synonyms (paired mesoderm homeobox protein 2B, PHOX2B homeodomain protein, neuroblastoma Phox, neuroblastoma paired-type homeobox protein, paired like homeobox2B, paired mesoderm homeobox 2b, CCHS, NBLST2, NBPhox, PMX2B,)
• NCBI Gene ID: 8929
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99453
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

paired like homeobox 2B interacts with:

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