MBD4, methyl-CpG binding domain 4, DNA glycosylase

MBD4, methyl-CpG binding domain 4, DNA glycosylase

• The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

• Gene Synonyms (methyl-CpG-binding domain protein 4, 3,N(4)-ethenocytosine glycosylase, G/5-fluorouracil mismatch glycosylase with biphasic kinetics, G/T mismatch glycosylase, G/U mismatch glycosylase, methyl-CpG binding domain protein 4, methyl-CpG-binding endonuclease 1, methyl-CpG-binding protein MBD4, mismatch-specific DNA N-glycosylase, putative methyl-CpG binding protein, MED1,)
• NCBI Gene ID: 8930
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95243
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

methyl-CpG binding domain 4, DNA glycosylase interacts with:

• cell division cycle associated 2
  centrosomal protein 78
  kinesin family member 20A
  lysine demethylase 1A
  nicastrin
  nuclear RNA export factor 1
  protein kinase C, iota
  SIN3 transcription regulator family member A
  TBC1 domain family, member 7
  tripartite motif-containing 27
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin-like, containing PHD and RING finger domains, 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.