GRAP2, GRB2 related adaptor protein 2

GRAP2, GRB2 related adaptor protein 2

• This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

• Gene Synonyms (GRB2-related adapter protein 2, GRB-2-like protein, GRB2-related protein with insert domain, SH3-SH2-SH3 adapter Mona, SH3-SH2-SH3 adaptor molecule, adapter protein GRID, grf-40, grf40 adapter protein, growth factor receptor-binding protein, growth factor receptor-bound protein 2-related adaptor protein 2, hematopoietic cell-associated adapter protein GrpL, hematopoietic cell-associated adaptor protein GRPL, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38,)
• NCBI Gene ID: 9402
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6FI14
  UNIPROT ID#>>B7Z8E3
  UNIPROT ID#>>O75791
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

GRB2 related adaptor protein 2 interacts with:

• anaphase promoting complex subunit 1
  anaphase promoting complex subunit 16
  anaphase promoting complex subunit 2
  anaphase promoting complex subunit 5
  anaphase promoting complex subunit 7
  B cell linker
  BAG cochaperone 4
  BEN domain containing 5
  chibby family member 2
  coiled-coil alpha-helical rod protein 1
  component of oligomeric golgi complex 6
  cyclin D1 binding protein 1
  GRB2 associated binding protein 2
  GRB2 associated binding protein 3
  GRB2 associated regulator of MAPK1 subtype 1
  IKAROS family zinc finger 3
  interactor of HORMAD1 1
  itchy E3 ubiquitin protein ligase
  keratin associated protein 1-3
  keratin associated protein 4-11
  keratin associated protein 4-12
  keratinocyte proline rich protein
  KH RNA binding domain containing, signal transduction associated 1
  KH RNA binding domain containing, signal transduction associated 2
  large tumor suppressor kinase 2
  ligand of numb-protein X 1
  ligand of numb-protein X 2
  linker for activation of T cells
  lymphocyte transmembrane adaptor 1
  MAGE family member D1
  microtubule associated scaffold protein 2
  mitogen-activated protein kinase kinase kinase kinase 1
  N-acetylglucosamine kinase
  phenazine biosynthesis like protein domain containing
  proline rich 35
  protein tyrosine phosphatase non-receptor type 23
  RAD50 interactor 1
  Ras and Rab interactor 3
  receptor for activated C kinase 1
  ribonucleoprotein, PTB binding 1
  RNA binding protein, mRNA processing factor
  SH2 domain containing 4A
  sorting nexin 18
  sprouty RTK signaling antagonist 2
  SSX family member 2 interacting protein
  STAM binding protein
  TNFAIP3 interacting protein 1
  translin associated factor X interacting protein 1
  tripartite motif containing 68
  tuftelin interacting protein 11
  WW domain containing E3 ubiquitin protein ligase 2
  zinc finger and BTB domain containing 7B
  zinc finger protein 250
  zinc finger protein 319
  zinc finger protein 526

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.