ESPL1, extra spindle pole bodies like 1, separase

ESPL1, extra spindle pole bodies like 1, separase

• Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]

• Gene Synonyms (separin, caspase-like protein ESPL1, extra spindle pole bodies 1, separase, extra spindle pole bodies homolog 1, extra spindle poles like 1, extra spindle poles-like 1 protein, separin, cysteine protease, ESP1, SEPA,)
• NCBI Gene ID: 9700
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14674
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

extra spindle pole bodies like 1, separase interacts with:

• atypical chemokine receptor 3
  cyclin-dependent kinase 1
  extra spindle pole bodies 1, separase
  F-box protein 4
  F-box protein 7
  fuzzy planar cell polarity protein
  glucose-fructose oxidoreductase domain containing 1
  glutamine amidotransferase like class 1 domain containing 1
  inhibitor of Bruton tyrosine kinase
  interleukin 17 receptor A
  isoleucyl-tRNA synthetase 2, mitochondrial
  kinesin family member 19A
  kinesin family member 2C
  limb development membrane protein 1 like
  LY6/PLAUR domain containing 4
  non-SMC condensin I complex, subunit H
  nuclear RNA export factor 1
  pleckstrin homology domain containing A4
  praja ring finger ubiquitin ligase 1
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  small glutamine rich tetratricopeptide repeat containing beta
  terminal nucleotidyltransferase 5A
  tripartite motif containing 55
  tripartite motif containing 63
  tubulin tyrosine ligase-like family, member 7
  ubiquitin specific peptidase 21
  ubiquitin specific peptidase 28
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.