KMT2B, lysine methyltransferase 2B

KMT2B, lysine methyltransferase 2B

• This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]

• Gene Synonyms (histone-lysine N-methyltransferase 2B, WW domain binding protein 7, histone-lysine N-methyltransferase MLL4, lysine (K)-specific methyltransferase 2B, mixed lineage leukemia gene homolog 2, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4, myeloid/lymphoid or mixed-lineage leukemia protein 4, trithorax homologue 2, CXXC10, DYT28, HRX2, MLL1B, MLL2, MLL4, TRX2, WBP-7, WBP7,)
• NCBI Gene ID: 9757
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UMN6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lysine methyltransferase 2B interacts with:

• 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  centrosomal protein 135
  H3 clustered histone 14
  host cell factor C2
  metadherin
  nuclear receptor coactivator 6
  PAX interacting protein 1
  PAXIP1 associated glutamate rich protein 1
  pre-mRNA processing factor 40 homolog A
  prolyl 4-hydroxylase subunit alpha 3
  ribonuclease P/MRP subunit p14
  ring finger protein 123
  septin 8
  THO complex 2
  trinucleotide repeat containing adaptor 6A
  vir like m6A methyltransferase associated
  WD repeat domain 5
  WD repeat domain 82
  zinc finger protein 512B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.