DMTF1, cyclin D binding myb like transcription factor 1

DMTF1, cyclin D binding myb like transcription factor 1

• This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

• Gene Synonyms (cyclin-D-binding Myb-like transcription factor 1, cyclin D-binding Myb-like protein, cyclin-D-interacting Myb-like protein 1, hDMTF1, DMP1, DMTF, MRUL, hDMP1,)
• NCBI Gene ID: 9988
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D6W5P0
  UNIPROT ID#>>B3KMJ8
  UNIPROT ID#>>Q9Y222
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cyclin D binding myb like transcription factor 1 interacts with:

• activating transcription factor 7 interacting protein
  DNA methyltransferase 3 like
  metadherin
  steroid receptor RNA activator 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.