DDB2, damage specific DNA binding protein 2

DDB2, damage specific DNA binding protein 2

• This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

• Gene Synonyms (DNA damage-binding protein 2, DDB p48 subunit, UV-DDB 2, UV-damaged DNA-binding protein 2, damage-specific DNA binding protein 2, 48kDa, xeroderma pigmentosum group E protein, DDBB, UV-DDB2, XPE,)
• NCBI Gene ID: 1643
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92466
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

damage specific DNA binding protein 2 interacts with:

• apurinic/apyrimidinic endodeoxyribonuclease 2
  BAF nuclear assembly factor 1
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chromatin licensing and DNA replication factor 1
  COP1 E3 ubiquitin ligase
  COP9 signalosome subunit 2
  COP9 signalosome subunit 3
  COP9 signalosome subunit 4
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  COP9 signalosome subunit 7A
  COP9 signalosome subunit 7B
  COP9 signalosome subunit 8
  COPI coat complex subunit gamma 1
  cullin 4A
  cullin 4B
  cullin 5
  cyclin dependent kinase 11A
  damage specific DNA binding protein 1
  damage specific DNA binding protein 2
  DDB1 and CUL4 associated factor 13
  DET1 and DDB1 associated 1
  DNA cross-link repair 1C
  DNA topoisomerase I
  E1A binding protein p300
  E2F transcription factor 1
  emerin
  enhancer of zeste 2 polycomb repressive complex 2 subunit
  fibrinogen like 1
  G protein pathway suppressor 1
  G protein-coupled receptor kinase 5
  G2 and S-phase expressed 1
  H2A clustered histone 20
  H2A clustered histone 4
  H2B clustered histone 3
  H3 clustered histone 1
  H3 clustered histone 14
  H4 clustered histone 1
  heat shock protein family D (Hsp60) member 1
  histone deacetylase 1
  ISG15 ubiquitin like modifier
  jumonji and AT-rich interaction domain containing 2
  lysine acetyltransferase 7
  methyltransferase like 3
  MYC proto-oncogene, bHLH transcription factor
  N-terminal Xaa-Pro-Lys N-methyltransferase 1
  nuclear receptor subfamily 5 group A member 2
  p53 and DNA damage regulated 1
  POP1 homolog, ribonuclease P/MRP subunit
  prefoldin subunit 2
  prefoldin subunit 4
  prefoldin subunit 5
  progestin and adipoQ receptor family member 3
  proliferating cell nuclear antigen
  proteasome 20S subunit alpha 5
  proteasome 20S subunit beta 1
  proteasome 20S subunit beta 4
  protein phosphatase 4 regulatory subunit 3A
  pyruvate kinase M1/2
  ring finger protein 2
  ring finger protein 4
  ring-box 1
  saccharopine dehydrogenase (putative)
  septin 2
  spermatogenesis associated 6
  SPT3 homolog, SAGA and STAGA complex component
  SPT6 homolog, histone chaperone and transcription elongation factor
  sterile alpha motif domain containing 4A
  SUZ12 polycomb repressive complex 2 subunit
  T-box transcription factor 2
  t-complex 1
  tigger transposable element derived 3
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  ubiquitin conjugating enzyme E2 M
  ubiquitin specific peptidase 24
  ubiquitin specific peptidase 40
  ubiquitin specific peptidase 53
  UV radiation resistance associated
  WD repeat domain 76
  XPA, DNA damage recognition and repair factor
  XPC complex subunit, DNA damage recognition and repair factor
  X-ray repair cross complementing 5
  X-ray repair cross complementing 6
  zinc finger and BTB domain containing 17
  zinc finger containing ubiquitin peptidase 1
  zinc ribbon domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.