PKM, pyruvate kinase M1/2

PKM, pyruvate kinase M1/2

• This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]

• Gene Synonyms (pyruvate kinase PKM, OPA-interacting protein 3, PK, muscle type, cytosolic thyroid hormone-binding protein, epididymis secretory protein Li 30, pyruvate kinase 2/3, pyruvate kinase isozymes M1/M2, pyruvate kinase muscle isozyme, pyruvate kinase, muscle, thyroid hormone-binding protein 1, thyroid hormone-binding protein, cytosolic, tumor M2-PK, CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, p58,)
• NCBI Gene ID: 5315
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R5Z9
  UNIPROT ID#>>B4DNK4
  UNIPROT ID#>>V9HWB8
  UNIPROT ID#>>P14618
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pyruvate kinase M1/2 interacts with:

• A kinase (PRKA) anchor protein (gravin) 12
  AAR2 splicing factor
  acetyl-CoA acyltransferase 2
  acidic nuclear phosphoprotein 32 family member A
  adenylate kinase 3
  agrin
  aldehyde dehydrogenase 5 family member A1
  aldo-keto reductase family 1 member A1
  amidohydrolase domain containing 2
  anterior gradient 2, protein disulphide isomerase family member
  aurora kinase B
  autophagy related 16 like 1
  BAF nuclear assembly factor 1
  bromodomain containing 7
  casein kinase 1, epsilon
  CCCTC-binding factor
  cell division cycle 37, HSP90 cochaperone
  cell division cycle 73
  checkpoint kinase 2
  chromosome 9 open reading frame 64
  Cobl-like 1
  coiled-coil domain containing 8
  coiled-coil domain containing 88A
  COP9 signalosome subunit 5
  cullin 1
  cullin 2
  cullin 3
  cullin 5
  cullin 7
  cyclin-dependent kinase 1
  CYFIP related Rac1 interactor B
  cytochrome c oxidase assembly factor 6
  DAZ associated protein 1
  DEAD-box helicase 19B
  DNA polymerase epsilon 2, accessory subunit
  DnaJ heat shock protein family (Hsp40) member A3
  egl-9 family hypoxia inducible factor 1
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  elongator complex protein 1
  EPM2A glucan phosphatase, laforin
  eukaryotic translation initiation factor 4A3
  exosome component 5
  expressed sequence AI837181
  far upstream element binding protein 1
  Fas associated factor 1
  F-box protein 6
  F-box protein 7
  fumarylacetoacetate hydrolase domain containing 2A
  G protein subunit gamma 12
  glutathione S-transferase kappa 1
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 6
  immunoglobulin superfamily member 8
  importin 11
  IQ motif containing B1
  ISG15 ubiquitin like modifier
  isochorismatase domain containing 2
  La ribonucleoprotein 7, transcriptional regulator
  lactate dehydrogenase A like 6A
  ligand of numb-protein X 1
  lysine demethylase 8
  lysophospholipase 2
  methionine sulfoxide reductase B2
  methylphosphate capping enzyme
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase 7
  N-acetylglucosamine kinase
  N-acetylneuraminate synthase
  nemo like kinase
  N-myc downstream regulated 1
  NPL4 homolog, ubiquitin recognition factor
  nuclear receptor subfamily 2 group C member 2
  nuclear transport factor 2 like export factor 2
  nucleoporin 188
  obscurin like cytoskeletal adaptor 1
  olfactomedin 2
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  paired box 8
  papilin, proteoglycan like sulfated glycoprotein
  Parkinsonism associated deglycase
  PDZ and LIM domain 5
  peptidylprolyl isomerase A
  peptidylprolyl isomerase D
  perilipin 3
  peroxiredoxin 2
  peroxiredoxin 5
  peroxiredoxin 6
  phosphatase and tensin homolog
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  PML nuclear body scaffold
  POC1 centriolar protein B
  poly(A) specific ribonuclease subunit PAN2
  pre-mRNA processing factor 8
  progesterone receptor membrane component 1
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, non-ATPase 14
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase methylesterase 1
  PTEN induced kinase 1
  pyruvate kinase M1/2
  pyruvate kinase, muscle
  RAB10, member RAS oncogene family
  RAB7A, member RAS oncogene family
  Rac family small GTPase 1
  RAD23 homolog B, nucleotide excision repair protein
  Raf-1 proto-oncogene, serine/threonine kinase
  RAP1B, member of RAS oncogene family
  RecQ like helicase 4
  regulatory associated protein of MTOR complex 1
  RELA proto-oncogene, NF-kB subunit
  ribonuclease P/MRP subunit p14
  ribophorin I
  ring finger protein 123
  ring finger protein 185
  ring finger protein 4
  RIO kinase 1
  sex hormone binding globulin
  signal recognition particle 14
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  small ubiquitin like modifier 1
  snail family transcriptional repressor 1
  solute carrier family 3 member 2
  sorbin and SH3 domain containing 2
  staufen double-stranded RNA binding protein 1
  STIP1 homology and U-box containing protein 1
  superoxide dismutase 2
  survival of motor neuron 1, telomeric
  SUZ12 polycomb repressive complex 2 subunit
  telomeric repeat binding factor 1
  TERF1 interacting nuclear factor 2
  thioredoxin domain containing 12
  thiosulfate sulfurtransferase
  thymidine kinase 1
  TNF receptor associated protein 1
  TNFAIP3 interacting protein 2
  TRAF3 interacting protein 1
  transcription factor CP2
  transforming growth factor beta receptor 2
  transketolase
  translocated promoter region, nuclear basket protein
  transmembrane protein 205
  tripartite motif containing 25
  tripartite motif containing 28
  tripartite motif containing 35
  tripartite motif containing 44
  tripartite motif containing 63
  tripartite motif-containing 69
  tubulin alpha 4a
  tubulin beta class I
  tumor necrosis factor
  twinfilin actin binding protein 2
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin fold modifier 1
  ubiquitin like modifier activating enzyme 2
  ubiquitin protein ligase E3C
  ubiquitin specific peptidase 7
  valosin containing protein
  vir like m6A methyltransferase associated
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  Yes1 associated transcriptional regulator
  zinc finger CCCH-type containing 7A
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.