PPIA, peptidylprolyl isomerase A

PPIA, peptidylprolyl isomerase A

• This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

• Gene Synonyms (peptidyl-prolyl cis-trans isomerase A, PPIase A, T cell cyclophilin, cyclosporin A-binding protein, epididymis secretory sperm binding protein Li 69p, peptidylprolyl isomerase A (cyclophilin A), rotamase A, CYPA, CYPH, HEL-S-69p,)
• NCBI Gene ID: 5478
• Species: Homo sapiens (Human)
• UNIPROT ID#>>V9HWF5
  UNIPROT ID#>>P62937
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

peptidylprolyl isomerase A interacts with:

• A kinase (PRKA) anchor protein (gravin) 12
  AAR2 splicing factor
  acetyl-CoA acyltransferase 2
  acyl-CoA thioesterase 1
  adenylate kinase 3
  anterior gradient 2, protein disulphide isomerase family member
  armadillo repeat containing 8
  autophagy related 16 like 1
  BAF chromatin remodeling complex subunit BCL7B
  bone morphogenetic protein receptor, type 1A
  casein kinase 1, epsilon
  charged multivesicular body protein 4A
  coiled-coil domain containing 15
  cold shock domain containing E1
  complexin 1
  COP9 signalosome subunit 5
  COP9 signalosome subunit 7B
  cullin 1
  cullin 3
  cullin 4B
  cullin 7
  cyclin-dependent kinase 1
  cysteinyl-tRNA synthetase 2, mitochondrial
  DDB1 and CUL4 associated factor 15
  DEAD-box helicase 46
  DExD/H-box helicase 58
  distal membrane arm assembly complex 2 like
  dual specificity phosphatase 28
  dynamin 1 like
  elongation factor Tu GTP binding domain containing 2
  ERBB receptor feedback inhibitor 1
  erythrocyte membrane protein band 4.1 like 4B
  eukaryotic translation initiation factor 4A3
  expressed sequence AI837181
  G3BP stress granule assembly factor 1
  glyoxylate and hydroxypyruvate reductase
  HEAT repeat containing 5A
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heme binding protein 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  interferon induced with helicase C domain 1
  isochorismatase domain containing 2
  kynureninase
  ligand of numb-protein X 1
  MAD2L1 binding protein
  MAPK interacting serine/threonine kinase 1
  methylphosphate capping enzyme
  methyltransferase like 14
  mitochondrial antiviral signaling protein
  NEDD4 binding protein 2 like 2
  nuclear receptor binding SET domain protein 2
  nuclear receptor subfamily 1 group I member 2
  nuclear receptor subfamily 2 group C member 2
  obscurin like cytoskeletal adaptor 1
  palmitoyl-protein thioesterase 1
  Parkinsonism associated deglycase
  patched 1
  PAX interacting protein 1
  peptidylprolyl isomerase A
  peroxiredoxin 5
  PIH1 domain containing 1
  pirin
  plasmanylethanolamine desaturase 1
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 19
  pre-mRNA processing factor 8
  prolactin receptor
  proline rich 13
  proteasome 26S subunit, non-ATPase 4
  protein inhibitor of activated STAT 2
  protein kinase C zeta
  protein kinase N3
  protein phosphatase 3 catalytic subunit alpha
  protein phosphatase 3 regulatory subunit B, alpha
  protein tyrosine phosphatase receptor type N
  prothymosin alpha
  PTEN induced kinase 1
  RAB10, member RAS oncogene family
  RAB5C, member RAS oncogene family
  RAD23 homolog B, nucleotide excision repair protein
  RAD52 homolog, DNA repair protein
  RAN, member RAS oncogene family
  RB transcriptional corepressor 1
  RecQ like helicase 4
  replication protein A2
  ribosomal protein L23a
  ring finger and CCCH-type domains 1
  ring finger protein 4
  RNA binding motif protein 4
  S100 calcium binding protein A8
  serine protease 23
  sorting nexin 3
  splicing factor proline and glutamine rich
  SPT5 homolog, DSIF elongation factor subunit
  SRSF protein kinase 1
  SRSF protein kinase 2
  sterol O-acyltransferase 1
  succinate dehydrogenase complex flavoprotein subunit A
  superoxide dismutase 1
  superoxide dismutase 2
  suppressor of Ty 5, DSIF elongation factor subunit
  syntaxin 3
  TAR DNA binding protein
  t-complex 1
  telomerase reverse transcriptase
  TNFAIP3 interacting protein 2
  transcription factor 4
  transcription factor CP2
  transgelin 2
  translocated promoter region, nuclear basket protein
  tripartite motif containing 25
  tropomodulin 2
  Ts translation elongation factor, mitochondrial
  tubulin alpha 1b
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 N
  ubiquitin specific peptidase 4
  vascular cell adhesion molecule 1
  vimentin
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  Yes1 associated transcriptional regulator
  YY1 transcription factor
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 875
  zyg-11 related cell cycle regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.