USP7, ubiquitin specific peptidase 7

USP7, ubiquitin specific peptidase 7

• The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016]

• Gene Synonyms (ubiquitin carboxyl-terminal hydrolase 7, Herpes virus-associated ubiquitin-specific protease, deubiquitinating enzyme 7, ubiquitin specific peptidase 7 (herpes virus-associated), ubiquitin specific protease 7 (herpes virus-associated), ubiquitin thioesterase 7, ubiquitin-specific-processing protease 7, HAFOUS, HAUSP, TEF1,)
• NCBI Gene ID: 7874
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7ZAX6
  UNIPROT ID#>>Q6U8A4
  UNIPROT ID#>>B7Z855
  UNIPROT ID#>>Q93009
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin specific peptidase 7 interacts with:

• abraxas 2, BRISC complex subunit
  ACD shelterin complex subunit and telomerase recruitment factor
  actin like 8
  ADP ribosylation factor like GTPase 6 interacting protein 4
  AF4/FMR2 family member 4
  A-kinase anchoring protein 1
  aldehyde dehydrogenase 1 family member L1
  alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  ankyrin repeat and sterile alpha motif domain containing 1A
  anterior gradient 2, protein disulphide isomerase family member
  aryl hydrocarbon receptor nuclear translocator 2
  ATPase H+ transporting V1 subunit D
  autophagy related 10
  axin 1
  BCL2 like 14
  BCL6 corepressor
  BCL6 corepressor like 1
  BEN domain containing 5
  BRCA1/BRCA2-containing complex subunit 3
  BRISC and BRCA1 A complex member 1
  BRISC and BRCA1 A complex member 2
  bromodomain and WD repeat domain containing 3
  bromodomain containing 7
  BUB3 mitotic checkpoint protein
  cAMP responsive element binding protein 3 like 3
  CD2-associated protein
  cell division cycle 37, HSP90 cochaperone
  centrosomal protein 112
  centrosomal protein 83
  checkpoint kinase 2
  checkpoint with forkhead and ring finger domains
  chromobox 8
  claspin
  coiled-coil domain containing 6
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  cullin 3
  cullin 4A
  cullin 4B
  CWC22 spliceosome associated protein homolog
  cyclic GMP-AMP synthase
  dCTP pyrophosphatase 1
  DDB1 and CUL4 associated factor 4
  DEAD-box helicase 24
  DEAD-box helicase 4
  DEAH-box helicase 40
  dedicator of cytokinesis 7
  dicer 1, ribonuclease III
  DISC1 scaffold protein
  DnaJ heat shock protein family (Hsp40) member A3
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  exportin for tRNA
  family with sequence similarity 170 member A
  Fas binding factor 1
  FAST kinase domains 2
  F-box protein 38
  forkhead box P3
  G patch domain and KOW motifs
  growth arrest specific 2 like 1
  guanine monophosphate synthase
  gypsy retrotransposon integrase 1
  H2A clustered histone 20
  H2A clustered histone 4
  H2B clustered histone 21
  H2B.U histone 1
  H4 clustered histone 1
  heat shock protein family H (Hsp110) member 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histone deacetylase 5
  histone deacetylase 6
  homocysteine inducible ER protein with ubiquitin like domain 1
  HtrA serine peptidase 2
  hypoxia inducible factor 1 subunit alpha inhibitor
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  insulin receptor substrate 2
  intraflagellar transport 43
  IQ motif containing GTPase activating protein 1
  junction plakoglobin
  kelch domain containing 10
  kelch like family member 8
  KH RNA binding domain containing, signal transduction associated 2
  KIAA2013
  kinesin family member 23
  kinesin family member 3A
  ligand dependent nuclear receptor corepressor
  lysine acetyltransferase 5
  lysine demethylase 1A
  lysine demethylase 6B
  lysine methyltransferase 2E (inactive)
  MAGE family member D2
  MAGE family member E1
  MAGE family member L2
  mediator complex subunit 26
  mediator of DNA damage checkpoint 1
  membrane associated ring-CH-type finger 7
  methyl-CpG binding domain 4, DNA glycosylase
  mex-3 RNA binding family member C
  microtubule actin crosslinking factor 1
  microtubule affinity regulating kinase 4
  MINDY lysine 48 deubiquitinase 4
  minichromosome maintenance complex binding protein
  mitochondrial carrier 1
  MMS19 homolog, cytosolic iron-sulfur assembly component
  myoneurin
  myosin IIIA
  MYST/Esa1 associated factor 6
  Nanog homeobox
  NFKB activating protein
  N-terminal EF-hand calcium binding protein 2
  NUAK family kinase 2
  nuclear speckle splicing regulatory protein 1
  O-linked N-acetylglucosamine (GlcNAc) transferase
  opioid growth factor receptor
  OTU deubiquitinase 4
  p21 (RAC1) activated kinase 5
  peptidylprolyl isomerase like 4
  PHD finger protein 7
  PHD finger protein 8
  phosphatidylinositol transfer protein beta
  phosphoglycerate dehydrogenase
  PIH1 domain containing 1
  plakophilin 4
  pleckstrin homology and RhoGEF domain containing G5
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing O1
  pleckstrin homology domain interacting protein
  pleckstrin homology like domain family B member 2
  polycomb group ring finger 1
  polycomb group ring finger 1
  polycomb group ring finger 3
  polycomb group ring finger 6
  POTE ankyrin domain family member B3
  POTE ankyrin domain family member C
  praja ring finger ubiquitin ligase 1
  progesterone receptor membrane component 1
  programmed cell death 6 interacting protein
  proline rich 12
  protein interacting with PRKCA 1
  protein phosphatase 6 regulatory subunit 3
  pyrin and HIN domain family member 1
  Rac/Cdc42 guanine nucleotide exchange factor 6
  RAD18 E3 ubiquitin protein ligase
  RAD50 double strand break repair protein
  RANBP2-type and C3HC4-type zinc finger containing 1
  Rap associating with DIL domain
  RecQ like helicase 4
  ribonucleic acid export 1
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  ring finger protein 1
  ring finger protein 11
  ring finger protein 126
  ring finger protein 168
  ring finger protein 169
  ring finger protein 220
  RING1 and YY1 binding protein
  RNA binding motif protein 11
  RNA binding protein with serine rich domain 1
  round spermatid basic protein 1
  RuvB like AAA ATPase 2
  Scm polycomb group protein like 2
  SEM1 26S proteasome complex subunit
  SH3 domain containing GRB2 like, endophilin B1
  sirtuin 1
  sirtuin 6
  sirtuin 7
  splicing factor 3b subunit 3
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  synoviolin 1
  syntaphilin
  thiamine triphosphatase
  thioredoxin like 1
  THO complex 2
  thyroid hormone receptor interactor 12
  TNF receptor associated factor 4
  TNF receptor associated protein 1
  TNFAIP3 interacting protein 2
  TRAF family member associated NFKB activator
  TRAF interacting protein
  transcription elongation factor A like 1
  transcription elongation factor A like 4
  transcription factor 25
  transformation/transcription domain associated protein
  transformed mouse 3T3 cell double minute 2
  transmembrane protein 87A
  tripartite motif containing 11
  tripartite motif containing 22
  tripartite motif containing 31
  tripartite motif containing 35
  tripartite motif containing 54
  tripartite motif containing 55
  tripartite motif containing 63
  tripartite motif containing 8
  tRNA splicing endonuclease subunit 15
  TSPY like 5
  tuftelin interacting protein 11
  UBA domain containing 1
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 S
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 19
  ubiquitin specific peptidase 21
  ubiquitin specific peptidase 24
  ubiquitin specific peptidase 28
  ubiquitin specific peptidase 7
  ubiquitin specific peptidase 9 X-linked
  UV stimulated scaffold protein A
  vir like m6A methyltransferase associated
  VPS29 retromer complex component
  VPS53 subunit of GARP complex
  WD repeat containing antisense to TP53
  WD repeat domain 1
  WD repeat domain 74
  WD repeat domain 76
  WT1 associated protein
  WW domain containing E3 ubiquitin protein ligase 2
  Y-box binding protein 3
  YLP motif containing 1
  YY1 associated factor 2
  ZFP2 zinc finger protein
  zinc finger and BTB domain containing 38
  zinc finger and BTB domain containing 44
  zinc finger CCCH-type containing 11A
  zinc finger CCHC-type containing 8
  zinc finger MYND-type containing 8
  zinc finger protein 169
  zinc finger protein 394
  zinc finger protein 423
  zinc finger protein 594
  zinc finger protein 609

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.