RPN1, ribophorin I

RPN1, ribophorin I

• This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]

• Gene Synonyms (dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, RPN-I, dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit, oligosaccharyltransferase 1 homolog, oligosaccharyltransferase complex subunit (non-catalytic), ribophorin-1, OST1, RBPH1,)
• NCBI Gene ID: 6184
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P04843
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ribophorin I interacts with:

• 3-hydroxyacyl-CoA dehydratase 1
  AAR2 splicing factor
  adhesion regulating molecule 1
  AFG3 like matrix AAA peptidase subunit 2
  agrin
  ankyrin repeat and SOCS box containing 11
  ankyrin repeat and SOCS box containing 5
  anterior gradient 2, protein disulphide isomerase family member
  ATP synthase membrane subunit g
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3B
  ATPase H+ transporting V0 subunit d1
  autophagy related 16 like 1
  B cell receptor associated protein 29
  BAG cochaperone 6
  bromodomain containing 7
  calreticulin 3
  CCCTC-binding factor
  cell division cycle 73
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  coiled-coil domain containing 47
  COP9 signalosome subunit 5
  cullin 3
  derlin 1
  DExD-box helicase 39A
  DExD-box helicase 39B
  double PHD fingers 1
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  ER degradation enhancing alpha-mannosidase like protein 3
  eukaryotic translation initiation factor 3 subunit M
  EvC ciliary complex subunit 2
  FAD dependent oxidoreductase domain containing 2
  F-box protein 25
  F-box protein 6
  F-box protein 7
  glutamate rich WD repeat containing 1
  glutathione S-transferase kappa 1
  H4 clustered histone 1
  heat shock protein 90 beta family member 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  hydroxysteroid 17-beta dehydrogenase 12
  importin 9
  insulin induced gene 2
  integrin alpha FG-GAP repeat containing 1
  interferon induced transmembrane protein 3
  keratin associated protein 1-3
  leucine rich repeat containing G protein-coupled receptor 4
  limb development membrane protein 1 like
  malectin
  methylphosphate capping enzyme
  methyltransferase like 14
  mitochondrial carrier 1
  mitochondrial carrier 2
  MMS19 homolog, cytosolic iron-sulfur assembly component
  NADH:ubiquinone oxidoreductase subunit A12
  negative elongation factor complex member B
  neurochondrin
  NODAL modulator 1
  NODAL modulator 2
  nuclear receptor subfamily 2 group C member 2
  obscurin like cytoskeletal adaptor 1
  oligosaccharyltransferase complex subunit 4, non-catalytic
  OS9 endoplasmic reticulum lectin
  OTU deubiquitinase with linear linkage specificity like
  phosphoethanolamine/phosphocholine phosphatase 1
  pleckstrin homology domain containing A4
  potassium channel tetramerization domain containing 10
  PR/SET domain 16
  pre-mRNA processing factor 19
  proteasome 26S subunit, non-ATPase 14
  protein disulfide isomerase family A member 6
  protein tyrosine phosphatase non-receptor type 23
  protein tyrosine phosphatase non-receptor type 5
  PTEN induced kinase 1
  RAB1B, member RAS oncogene family
  RAD18 E3 ubiquitin protein ligase
  RecQ like helicase 4
  retinol dehydrogenase 13
  ribophorin II
  ribosomal protein L35
  ribosomal protein S6 kinase B2
  ring finger and CCCH-type domains 1
  ring finger protein 123
  ring finger protein 185
  SAC1 suppressor of actin mutations 1-like (yeast)
  saccharopine dehydrogenase (putative)
  secretory carrier membrane protein 2
  SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
  signal sequence receptor subunit 1
  signal sequence receptor subunit 2
  signal sequence receptor subunit 3
  signal sequence receptor subunit 4
  single Ig and TIR domain containing
  SLX4 interacting protein
  small glutamine rich tetratricopeptide repeat containing alpha
  snail family transcriptional repressor 1
  solute carrier family 15 member 3
  solute carrier family 25 member 1
  staphylococcal nuclease and tudor domain containing 1
  staufen double-stranded RNA binding protein 1
  STT3 oligosaccharyltransferase complex catalytic subunit B
  succinate dehydrogenase complex flavoprotein subunit A
  succinate-CoA ligase GDP-forming subunit beta
  SUMO specific peptidase 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  t-complex 1
  tectonic family member 1
  tectonic family member 2
  tectonic family member 3
  testis expressed 101
  thioredoxin interacting protein
  thymopoietin
  TNFAIP3 interacting protein 2
  trans-2,3-enoyl-CoA reductase
  transcription factor CP2
  transforming growth factor beta 1
  translocase of outer mitochondrial membrane 22
  translocase of outer mitochondrial membrane 40
  translocase of outer mitochondrial membrane 5
  transmembrane and coiled-coil domains 1
  transmembrane p24 trafficking protein 2
  transmembrane phosphatase with tensin homology
  transmembrane protein 41B
  transmembrane protein 63B
  transmembrane protein 67
  tripartite motif containing 11
  Tu translation elongation factor, mitochondrial
  tubulin alpha 1c
  tubulin gamma 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 1
  ubiquilin 2
  ubiquilin 4
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L3
  ubiquitin like 4A
  ubiquitin specific peptidase 49
  unc-93 homolog B1, TLR signaling regulator
  valosin containing protein
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  voltage dependent anion channel 3
  WD repeat and SOCS box containing 2
  WW domain containing oxidoreductase
  Yes1 associated transcriptional regulator
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.