SSR1, signal sequence receptor subunit 1

SSR1, signal sequence receptor subunit 1

• The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

• Gene Synonyms (translocon-associated protein subunit alpha, SSR alpha subunit, SSR-alpha, TRAP alpha, signal sequence receptor subunit alpha, signal sequence receptor, alpha, translocon-associated protein alpha subunit, TRAPA,)
• NCBI Gene ID: 6745
• Species: Homo sapiens (Human)
• UNIPROT ID#>>C9JBX5
  UNIPROT ID#>>P43307
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

signal sequence receptor subunit 1 interacts with:

• AAR2 splicing factor
  acyl-CoA dehydrogenase family member 9
  ATP synthase membrane subunit g
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3B
  ATPase H+ transporting V0 subunit d1
  bromodomain containing 7
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  clusterin associated protein 1
  cullin 3
  cullin associated and neddylation dissociated 1
  dual specificity phosphatase 23
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  ER degradation enhancing alpha-mannosidase like protein 1
  ER degradation enhancing alpha-mannosidase like protein 3
  ERGIC and golgi 3
  F-box protein 6
  FKBP prolyl isomerase 8
  heat shock protein family A (Hsp70) member 13
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histocompatibility minor 13
  L3MBTL histone methyl-lysine binding protein 1
  limb development membrane protein 1 like
  listerin E3 ubiquitin protein ligase 1
  magnesium transporter 1
  mediator complex subunit 23
  mediator of DNA damage checkpoint 1
  methyltransferase like 14
  nucleoporin 54
  OTU deubiquitinase with linear linkage specificity like
  prohibitin 2
  RecQ like helicase 4
  SEC61 translocon subunit beta
  sideroflexin 1
  signal sequence receptor subunit 3
  signal sequence receptor subunit 4
  t-complex 1
  tectonic family member 3
  thioredoxin related transmembrane protein 1
  TNFAIP3 interacting protein 2
  trans-2,3-enoyl-CoA reductase
  transmembrane protein 216
  tripartite motif containing 28
  tubulin alpha 1a
  tubulin, gamma complex associated protein 5
  ubiquinol-cytochrome c reductase core protein 2
  UTP14A small subunit processome component
  vir like m6A methyltransferase associated
  voltage dependent anion channel 3
  WW domain containing oxidoreductase
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.