STUB1, STIP1 homology and U-box containing protein 1

STUB1, STIP1 homology and U-box containing protein 1

• This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]

• Gene Synonyms (CHIP, HSPABP2, NY-CO-7, SCA48, SCAR16, SDCCAG7, UBOX1, E3 ubiquitin-protein ligase CHIP, CLL-associated antigen KW-8, RING-type E3 ubiquitin transferase CHIP, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase, antigen NY-CO-7, carboxy terminus of Hsp70-interacting protein, heat shock protein A binding protein 2 (c-terminal), serologically defined colon cancer antigen 7,)
• NCBI Gene ID: 10273
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UNE7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

STIP1 homology and U-box containing protein 1 interacts with:

• A kinase (PRKA) anchor protein (yotiao) 9
  abhydrolase domain containing 15
  ACD shelterin complex subunit and telomerase recruitment factor
  achalasia, adrenocortical insufficiency, alacrimia
  adenosylhomocysteinase like 1
  AHNAK nucleoprotein (desmoyokin)
  aldehyde dehydrogenase 1 family member L1
  ankyrin repeat and SOCS box containing 10
  ankyrin repeat and SOCS box containing 4
  argonaute RISC component 1
  ATCAY kinesin light chain interacting caytaxin
  ATPase, class VI, type 11C
  autophagy and beclin 1 regulator 1
  BCL2-associated athanogene 2
  beta-secretase 1
  bone morphogenetic protein receptor, type 1A
  brain-specific angiogenesis inhibitor 1-associated protein 2
  bridging integrator 1
  caspase recruitment domain family member 11
  C-C motif chemokine ligand 28
  cell division cycle 37 like 1
  cell division cycle 37, HSP90 cochaperone
  cellular inhibitor of PP2A
  cellular nucleic acid binding protein
  centromere protein U
  ceroid-lipofuscinosis, neuronal 6
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  C-type lectin domain family 1 member B
  cyclin dependent kinase 20
  cyclin-dependent kinase 6
  DExD/H-box helicase 58
  DExD/H-box helicase 60
  DExH-box helicase 30
  DNA damage induced apoptosis suppressor
  DnaJ heat shock protein family (Hsp40) member B6
  DnaJ heat shock protein family (Hsp40) member C13
  DnaJ heat shock protein family (Hsp40) member C25
  DnaJ heat shock protein family (Hsp40) member C5
  DnaJ heat shock protein family (Hsp40) member C9
  dynein axonemal assembly factor 4
  E2F transcription factor 8
  egl-9 family hypoxia inducible factor 3
  eukaryotic translation initiation factor 6
  EvC ciliary complex subunit 2
  family with sequence homology 193, member A
  Fas associated factor 1
  FAST kinase domains 5
  F-box and WD-40 domain protein 11
  F-box protein 2
  F-box protein 27
  folliculin
  forkhead box P3
  fos-like antigen 2
  glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
  glutamate rich 1
  G-protein signalling modulator 2 (AGS3-like, C. elegans)
  GRB10 interacting GYF protein 1
  heat shock protein 8
  heat shock protein family A (Hsp70) member 4 like
  helicase (DNA) B
  heparanase
  hepatitis A virus cellular receptor 1
  homeodomain interacting protein kinase 2
  HSPA (Hsp70) binding protein 1
  hydroxysteroid dehydrogenase like 1
  hypoxia inducible factor 1 subunit alpha inhibitor
  ilvB (bacterial acetolactate synthase)-like
  integrator complex subunit 5
  Josephin domain containing 2
  katanin catalytic subunit A1
  kelch domain containing 2
  kelch like family member 29
  kelch like family member 34
  KH RNA binding domain containing, signal transduction associated 1
  kinase suppressor of ras 1
  kinesin family member C3
  kinesin family member C5B
  laminin, beta 2
  leucine rich repeat kinase 1
  leucine rich repeat kinase 2
  lysine methyltransferase 2E (inactive)
  MALT1 paracaspase
  methyltransferase like 3
  mitochondrial carrier 2
  mitochondrial ribosomal protein L19
  mitogen-activated protein kinase 7
  mitogen-activated protein kinase kinase kinase 2
  mitogen-activated protein kinase kinase kinase 21
  musashi RNA-binding protein 2
  MYC-associated zinc finger protein (purine-binding transcription factor)
  myeloid leukemia factor 2
  myocardin
  N-acetyltransferase 16 (putative)
  NAD synthetase 1
  NADPH oxidase 5
  NHL repeat containing E3 ubiquitin protein ligase 1
  NHS-like 1
  NLR family pyrin domain containing 3
  NPR2 like, GATOR1 complex subunit
  nuclear RNA export factor 1
  NudC domain containing 2
  Obg like ATPase 1
  olfactomedin 3
  orthodenticle homeobox 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  parkin coregulated
  Parkinsonism associated deglycase
  pellino E3 ubiquitin protein ligase family member 3
  PH domain and leucine rich repeat protein phosphatase 1
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  pleckstrin homology domain containing A4
  poly(ADP-ribose) polymerase family member 10
  pre-mRNA processing factor 19
  pre-mRNA processing factor 8
  proliferation-associated 2G4
  proline-rich coiled-coil 2B
  proprotein convertase subtilisin/kexin type 9
  prostaglandin E synthase 3
  protection of telomeres 1
  protein arginine methyltransferase 5
  RAD50 double strand break repair protein
  receptor interacting serine/threonine kinase 4
  regulator of G protein signaling 17
  replication protein A1
  replication protein A2
  replication protein A3
  replication termination factor 2
  required for meiotic nuclear division 5 homolog A
  Rho GTPase activating protein 17
  Rho GTPase activating protein 33
  rhomboid 5 homolog 2
  ribosomal protein L26
  ribosomal protein L31
  ribosomal protein L35
  ribosomal protein S24
  RUN and SH3 domain containing 1
  Sec23 homolog A, COPII coat complex component
  SEC24 homolog A, COPII coat complex component
  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J
  SHANK associated RH domain interactor
  sirtuin 6
  SMAD specific E3 ubiquitin protein ligase 1
  SMG5 nonsense mediated mRNA decay factor
  Snf2-related CREBBP activator protein
  solute carrier family 27 member 3
  Sp7 transcription factor
  stathmin 2
  staufen double-stranded RNA binding protein 1
  STIP1 homology and U-box containing protein 1
  stromal cell-derived factor 2-like 1
  sulfiredoxin 1
  SUMO specific peptidase 3
  TATA-box binding protein associated factor 6
  taxilin gamma
  TERF1 interacting nuclear factor 2
  thioredoxin 2
  TNFAIP3 interacting protein 2
  toll like receptor 9
  topoisomerase (DNA) II binding protein 1
  trans-acting transcription factor 1
  transcription factor 4
  translocase of outer mitochondrial membrane 40
  trinucleotide repeat containing 6b
  trypsin domain containing 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 Q1
  ubiquitin conjugating enzyme E2 W
  ubiquitin specific peptidase 19
  ubiquitin-associated protein 2-like
  ubiquitination factor E4B
  UBX domain protein 10
  UBX domain protein 2A
  vacuolar protein sorting 4A
  vesicle transport through interaction with t-SNAREs 1B
  vitamin K epoxide reductase complex, subunit 1
  WD repeat domain 34
  WD repeat domain containing 83
  WW domain containing oxidoreductase
  Yes1 associated transcriptional regulator
  Yip1 interacting factor homolog B (S. cerevisiae)
  zinc finger and BTB domain containing 38
  zinc finger protein 275

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.