MAP3K2, mitogen-activated protein kinase kinase kinase 2

MAP3K2, mitogen-activated protein kinase kinase kinase 2

• The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

• Gene Synonyms (MEKK2, MEKK2B, mitogen-activated protein kinase kinase kinase 2, MAP/ERK kinase kinase 2, MAPK/ERK kinase kinase 2, MEK kinase 2, MEKK 2,)
• NCBI Gene ID: 10746
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RAH0
  UNIPROT ID#>>Q9Y2U5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase kinase 2 interacts with:

• chibby family member 1, beta catenin antagonist
  mitogen-activated protein kinase kinase 4
  mitogen-activated protein kinase kinase kinase 2
  NEDD4 like E3 ubiquitin protein ligase
  RAB3A interacting protein
  serine/threonine kinase 38
  serine/threonine kinase 38 like
  SMAD specific E3 ubiquitin protein ligase 1
  STIP1 homology and U-Box containing protein 1
  TNF receptor associated factor 7
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  WNK lysine deficient protein kinase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.