RAB21, RAB21, member RAS oncogene family

RAB21, RAB21, member RAS oncogene family

• This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]

• Gene Synonyms (ras-related protein Rab-21, GTP-binding protein RAB21,)
• NCBI Gene ID: 23011
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RBA9
  UNIPROT ID#>>Q9UL25
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RAB21, member RAS oncogene family interacts with:

• adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  dynein light chain roadblock-type 1
  hook microtubule tethering protein 1
  hook microtubule tethering protein 3
  leucine rich repeat kinase 2
  pleckstrin homology domain containing A4
  RAB guanine nucleotide exchange factor 1
  RAB2B, member RAS oncogene family
  RUS family member 1
  solute carrier family 22 member 16
  VAC14 component of PIKFYVE complex
  vir like m6A methyltransferase associated
  V-set and immunoglobulin domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.