APPL1, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

APPL1, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

• The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DCC-interacting protein 13-alpha, AKT2 interactor, adapter protein containing PH domain, PTB domain and leucine zipper motif 1, adaptor protein containing pH domain, PTB domain and leucine zipper motif 1, adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1, dip13-alpha, signaling adaptor protein DIP13alpha, APPL, DIP13alpha, MODY14,)
• NCBI Gene ID: 26060
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UKG1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 interacts with:

• acireductone dioxygenase 1
  adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
  adiponectin receptor 1
  adiponectin receptor 2
  basic leucine zipper ATF-like transcription factor 3
  bromodomain and WD repeat domain containing 1
  chromosome 16 open reading frame 70
  CKLF like MARVEL transmembrane domain containing 4
  dihydropyrimidinase like 5
  docking protein 3
  docking protein 7
  eukaryotic translation initiation factor 3 subunit C like
  family with sequence similarity 167 member A
  GIPC PDZ domain containing family member 2
  INO80 complex subunit E
  Kruppel like factor 15
  KxDL motif containing 1
  MAGE family member C3
  pleckstrin homology and FYVE domain containing 2
  pleckstrin homology domain containing A4
  PNMA family member 5
  RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
  RHEB like 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  S-phase cyclin A associated protein in the ER
  transmembrane protein 17
  two pore segment channel 2
  ubiquitin conjugating enzyme E2 O
  zinc finger protein 829
  zinc finger protein 830

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.