HLA-DRB5, major histocompatibility complex, class II, DR beta 5

HLA-DRB5, major histocompatibility complex, class II, DR beta 5

• HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]

• Gene Synonyms (major histocompatibility complex, class II, DR beta 5, DR beta-5, HLA class II histocompatibility antigen, DR-5 beta chain, MHC class II antigen DRB5, HLA-DRB5*,)
• NCBI Gene ID: 3127
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q30154
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

major histocompatibility complex, class II, DR beta 5 interacts with:

• dual specificity phosphatase 13
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  pyruvate kinase M1/2
  signal transducer and activator of transcription 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  ubiquitin protein ligase E3 component n-recognin 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.