LBR, lamin B receptor

LBR, lamin B receptor

• The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (C14SR, DHCR14B, LMN2R, PHA, PHASK, TDRD18, delta(14)-sterol reductase LBR, 3-beta-hydroxysterol Delta (14)-reductase, C-14 sterol reductase, delta(14)-sterol reductase, delta-14-SR, integral nuclear envelope inner membrane protein, sterol C14-reductase, tudor domain containing 18,)
• NCBI Gene ID: 3930
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14739
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lamin B receptor interacts with:

• A-kinase anchoring protein 8 like
  basic helix-loop-helix family member a15
  bromodomain containing 7
  CCCTC-binding factor
  chromatin target of PRMT1
  chromobox 3
  chromobox 5
  complement component 1, q subcomponent binding protein
  COPI coat complex subunit epsilon
  C-type lectin domain family 3 member A
  cullin 7
  cyclin dependent kinase 20
  egl-9 family hypoxia inducible factor 3
  embryonic ectoderm development
  eukaryotic translation initiation factor 4A3
  EvC ciliary complex subunit 2
  formin binding protein 4
  G3BP stress granule assembly factor 1
  golgi transport 1B
  H3 clustered histone 1
  H4 clustered histone 1
  H4 clustered histone 14
  heterogeneous nuclear ribonucleoprotein R
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 4
  homeodomain interacting protein kinase 4
  huntingtin interacting protein K
  La ribonucleoprotein 7, transcriptional regulator
  lamin A/C
  lamin B receptor
  lamin B1
  limb development membrane protein 1 like
  LUC7 like
  MAD2 mitotic arrest deficient-like 1
  MAD2L1 binding protein
  methyl-CpG binding protein 2
  methylphosphate capping enzyme
  MYC proto-oncogene, bHLH transcription factor
  neurotrophic receptor tyrosine kinase 1
  NRAS proto-oncogene, GTPase
  nuclear receptor subfamily 2 group C member 2
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase with linear linkage specificity like
  patched 1
  pleckstrin homology domain containing A4
  prohibitin
  protamine 1
  proteasome 26S subunit, non-ATPase 3
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  pyruvate dehydrogenase E1 subunit alpha 1
  RecQ like helicase 4
  rhomboid domain containing 1
  ribosomal protein S6
  ring finger protein 4
  snail family transcriptional repressor 1
  solute carrier family 15 member 3
  SRSF protein kinase 1
  SRSF protein kinase 2
  tectonic family member 2
  tectonic family member 3
  transcription factor 3
  trans-golgi network protein 2
  transmembrane protein 17
  transmembrane protein 216
  transmembrane protein 41B
  tubulin alpha 1a
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  ubiquitin conjugating enzyme E2 A
  WW domain containing oxidoreductase
  zinc finger protein 579
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.