MARCKS, myristoylated alanine rich protein kinase C substrate

MARCKS, myristoylated alanine rich protein kinase C substrate

• The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (80K-L, MACS, PKCSL, PRKCSL, myristoylated alanine-rich C-kinase substrate, myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L), phosphomyristin, protein kinase C substrate, 80 kDa protein, light chain,)
• NCBI Gene ID: 4082
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P29966
  UNIPROT ID#>>Q6NVI1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

myristoylated alanine rich protein kinase C substrate interacts with:

• AAR2 splicing factor
  calcium homeostasis endoplasmic reticulum protein
  CCR4-NOT transcription complex subunit 3
  coiled-coil domain containing 9
  elongation factor Tu GTP binding domain containing 2
  F-box and WD repeat domain containing 11
  fibronectin type III domain containing 3B
  kinase suppressor of ras 1
  La ribonucleoprotein 7, transcriptional regulator
  mitogen-activated protein kinase 13
  neurotrophic receptor tyrosine kinase 1
  N-myristoyltransferase 1
  NRAS proto-oncogene, GTPase
  parkin RBR E3 ubiquitin protein ligase
  peroxiredoxin 1
  phosphoethanolamine/phosphocholine phosphatase 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  potassium channel tetramerization domain containing 10
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
  proteasome 20S subunit alpha 3
  protein kinase C alpha
  protein kinase C beta
  protein kinase C zeta
  protein kinase cAMP-activated catalytic subunit alpha
  protein kinase N1
  protein phosphatase 2 catalytic subunit alpha
  PTEN induced kinase 1
  RAB34, member RAS oncogene family
  ras homolog family member U
  replication protein A2
  retinoic acid induced 14
  ribosomal protein L38
  ribosomal protein L5
  ribosomal protein S12
  ribosomal protein S6 kinase A2
  ring finger protein 20
  ring finger protein 40
  RPTOR independent companion of MTOR complex 2
  RuvB like AAA ATPase 1
  secreted phosphoprotein 1
  sideroflexin 1
  solute carrier family 4 member 1 adaptor protein
  structure specific recognition protein 1
  telomerase associated protein 1
  thioredoxin domain containing 16
  transducer of ERBB2, 1
  tripartite motif containing 29
  tubulin gamma complex associated protein 3
  U2AF homology motif kinase 1
  ubiquilin 2
  WD repeat domain 5
  WD repeat domain 77
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.