PRKN, parkin RBR E3 ubiquitin protein ligase

PRKN, parkin RBR E3 ubiquitin protein ligase

• The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]

• Gene Synonyms (AR-JP, LPRS2, PARK2, PDJ, E3 ubiquitin-protein ligase parkin, Parkinson disease (autosomal recessive, juvenile) 2, parkin, parkinson juvenile disease protein 2, parkinson protein 2 E3 ubiquitin protein ligase, parkinson protein 2, E3 ubiquitin protein ligase (parkin),)
• NCBI Gene ID: 5071
• Species: Homo sapiens (Human)
• UNIPROT ID#>>X5DR79
  UNIPROT ID#>>O60260
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

parkin RBR E3 ubiquitin protein ligase interacts with:

• actin beta like 2
  acylglycerol kinase
  adhesion regulating molecule 1
  adhesion regulating molecule 1
  alkylglycerone phosphate synthase
  aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  angiomotin
  apoptosis inducing factor mitochondria associated 1
  ariadne RBR E3 ubiquitin protein ligase 1
  ataxin 2
  ATP binding cassette subfamily E member 1
  ATP synthase membrane subunit f
  ATPase family AAA domain containing 1
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3B
  aurora kinase A
  aurora kinase B
  autophagy and beclin 1 regulator 1
  BAG cochaperone 2
  BAG cochaperone 5
  beclin 1
  calcium binding and coiled-coil domain 2
  calcium/calmodulin dependent serine protein kinase
  caseinolytic mitochondrial matrix peptidase chaperone subunit X
  caspase 14
  CDGSH iron sulfur domain 1
  centrosomal protein 55
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chondroitin polymerizing factor
  chromobox 1
  chromobox 3
  coiled-coil-helix-coiled-coil-helix domain containing 3
  complement component 1, q subcomponent binding protein
  copper metabolism domain containing 1
  cullin 1
  cyclin A1
  cytochrome b5 reductase 1
  cytoskeleton associated protein 4
  DEAD-box helicase 17
  DEAD-box helicase 47
  death associated protein 3
  DNA damage inducible transcript 4
  dynamin 1 like
  epidermal growth factor receptor
  epidermal growth factor receptor pathway substrate 15
  ezrin
  far upstream element binding protein 1
  Fas associated factor 1
  F-box and WD repeat domain containing 7
  F-box protein 4
  F-box protein 7
  fission, mitochondrial 1
  fizzy and cell division cycle 20 related 1
  gamma-butyrobetaine hydroxylase 1
  gasdermin A
  H2A clustered histone 1
  H4 clustered histone 11
  heat shock protein 90 beta family member 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 5
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein C like 1
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein R
  hexosaminidase D
  histone deacetylase 4
  histone deacetylase 6
  homer scaffold protein 1
  HtrA serine peptidase 2
  hydroxysteroid dehydrogenase like 2
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  insulin like growth factor 2 mRNA binding protein 1
  internexin neuronal intermediate filament protein alpha
  leucine rich pentatricopeptide repeat containing
  leucine rich repeat kinase 2
  MARCKS like 1
  matrin 3
  membrane associated ring-CH-type finger 5
  methylcrotonoyl-CoA carboxylase 2
  microtubule-associated protein 1B
  mitochondrial amidoxime reducing component 1
  mitochondrial antiviral signaling protein
  mitochondrial calcium uptake 1
  mitochondrial ribosomal protein L12
  mitochondrial ribosomal protein S15
  mitochondrial ribosomal protein S18B
  mitochondrial ribosomal protein S22
  mitochondrial ribosomal protein S23
  mitochondrial ribosomal protein S27
  mitochondrial ribosomal protein S28
  mitochondrial ribosomal protein S31
  mitochondrial ribosomal protein S7
  mitofusin 1
  mitofusin 2
  mitofusin 2
  mitogen-activated protein kinase 1
  myosin light chain 12A
  myosin light chain 12B
  NDUFA4 mitochondrial complex associated like 2
  nipsnap homolog 1
  NME1-NME2 readthrough
  nucleoside-triphosphatase, cancer-related
  nucleotide binding oligomerization domain containing 2
  nucleus accumbens associated 1
  optineurin
  oxidative stress induced growth inhibitor 1
  parkin coregulated
  parkin RBR E3 ubiquitin protein ligase
  Parkinsonism associated deglycase
  PAS domain containing serine/threonine kinase
  pentatricopeptide repeat domain 3
  peptidylprolyl isomerase A
  peroxiredoxin 2
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  phosphatase and tensin homolog
  phosphate cytidylyltransferase 2, ethanolamine
  phosphatidylinositol 3-kinase catalytic subunit type 3
  phosphoglycerate kinase 1
  phosphoglycerate mutase 1
  phospholipase C gamma 1
  phosphoribosyl pyrophosphate synthetase 1
  polo like kinase 1
  poly(A) binding protein cytoplasmic 1 like
  poly(rC) binding protein 1
  PRAME nuclear receptor transcriptional regulator
  pre-mRNA processing factor 19
  pre-mRNA processing factor 6
  profilin 1
  programmed cell death 2
  prohibitin 2
  prolactin induced protein
  proliferating cell nuclear antigen
  proline rich coiled-coil 2C
  propionyl-CoA carboxylase subunit alpha
  propionyl-CoA carboxylase subunit beta
  proteasomal ATPase associated factor 1
  proteasome 20S subunit alpha 1
  proteasome 20S subunit alpha 2
  proteasome 20S subunit alpha 3
  proteasome 20S subunit alpha 4
  proteasome 20S subunit alpha 5
  proteasome 20S subunit alpha 6
  proteasome 20S subunit alpha 7
  proteasome 20S subunit beta 1
  proteasome 20S subunit beta 2
  proteasome 20S subunit beta 3
  proteasome 20S subunit beta 4
  proteasome 20S subunit beta 5
  proteasome 20S subunit beta 6
  proteasome 20S subunit beta 7
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 10
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome 26S subunit, non-ATPase 9
  proteasome activator subunit 1
  proteasome activator subunit 2
  proteasome activator subunit 3
  protein disulfide isomerase family A member 4
  protein disulfide isomerase family A member 6
  protein interacting with PRKCA 1
  protein kinase AMP-activated catalytic subunit alpha 2
  protein kinase C substrate 80K-H
  protein tyrosine phosphatase non-receptor type 5
  PTEN induced kinase 1
  PTTG1 regulator of sister chromatid separation, securin
  pyruvate kinase M1/2
  RAB7A, member RAS oncogene family
  Rac family small GTPase 1
  RAD1 checkpoint DNA exonuclease
  RAD23 homolog A, nucleotide excision repair protein
  RAD23 homolog B, nucleotide excision repair protein
  RALY heterogeneous nuclear ribonucleoprotein
  RAN binding protein 2
  RANBP2-type and C3HC4-type zinc finger containing 1
  ras homolog family member T1
  ras homolog family member T2
  receptor interacting serine/threonine kinase 1
  receptor interacting serine/threonine kinase 3
  regulator of G protein signaling 2
  regulator of G protein signaling 3
  regulatory associated protein of MTOR complex 1
  REL proto-oncogene, NF-kB subunit
  replication factor C subunit 4
  reticulocalbin 2
  ribosomal protein L11
  ribosomal protein L12
  ribosomal protein L13
  ribosomal protein L22
  ribosomal protein L23a
  ribosomal protein L26 like 1
  ribosomal protein L4
  ribosomal protein L6
  ribosomal protein L7
  ribosomal protein L7a
  ribosomal protein L8
  ribosomal protein lateral stalk subunit P0
  ribosomal protein lateral stalk subunit P2
  ribosomal protein S13
  ribosomal protein S14
  ribosomal protein S16
  ribosomal protein S19
  ribosomal protein S2
  ribosomal protein S20
  ribosomal protein S25
  ribosomal protein S27a
  ribosomal protein S6
  ribosomal protein S8
  ring finger protein 31
  ring finger protein 41
  RNA binding motif protein 8A
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  septin 4
  septin 5
  septin 5
  sequestosome 1
  serine and arginine rich splicing factor 1
  serine and arginine rich splicing factor 2
  serine and arginine rich splicing factor 3
  serine and arginine rich splicing factor 9
  SERPINE1 mRNA binding protein 1
  SET nuclear proto-oncogene
  SIM bHLH transcription factor 2
  single stranded DNA binding protein 1
  small nuclear ribonucleoprotein U5 subunit 200
  small ubiquitin like modifier 1
  solute carrier family 25 member 1
  solute carrier family 25 member 13
  solute carrier family 25 member 24
  solute carrier family 25 member 3
  solute carrier family 6 member 3
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  splicing factor proline and glutamine rich
  STIP1 homology and U-box containing protein 1
  stomatin like 2
  synapsin I
  synaptotagmin 11
  synaptotagmin binding cytoplasmic RNA interacting protein
  synuclein alpha
  synuclein alpha interacting protein
  TANK binding kinase 1
  TAR DNA binding protein
  target of myb1 membrane trafficking protein
  Tax1 binding protein 1
  TBC1 domain family member 15
  t-complex 1
  terminal nucleotidyltransferase 5C
  thioredoxin
  thyroid hormone receptor interactor 13
  TNF receptor associated factor 2
  TNF receptor associated factor 3
  TNF receptor associated factor 6
  transcription factor 4
  transferrin receptor
  transglutaminase 3
  transketolase
  translocase of outer mitochondrial membrane 22
  translocase of outer mitochondrial membrane 40
  translocase of outer mitochondrial membrane 70
  trichoplein keratin filament binding
  triosephosphate isomerase 1
  tropomyosin 1
  tropomyosin 3
  tropomyosin 4
  Tu translation elongation factor, mitochondrial
  tubulin alpha 1a
  tubulin alpha 1c
  tubulin alpha 3d
  tubulin alpha 4a
  tubulin beta 1 class VI
  tubulin beta 4B class IVb
  tubulin beta 6 class V
  tubulin beta class I
  tubulin gamma 1
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin associated and SH3 domain containing A
  ubiquitin associated and SH3 domain containing B
  ubiquitin B
  ubiquitin C
  ubiquitin conjugating enzyme E2 A
  ubiquitin conjugating enzyme E2 B
  ubiquitin conjugating enzyme E2 C
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 E1
  ubiquitin conjugating enzyme E2 E2
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 G1
  ubiquitin conjugating enzyme E2 G2
  ubiquitin conjugating enzyme E2 H
  ubiquitin conjugating enzyme E2 J1
  ubiquitin conjugating enzyme E2 J2
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 L6
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 N
  ubiquitin conjugating enzyme E2 O
  ubiquitin conjugating enzyme E2 R2
  ubiquitin conjugating enzyme E2 S
  ubiquitin conjugating enzyme E2 T
  ubiquitin conjugating enzyme E2 V1
  ubiquitin conjugating enzyme E2 Z
  ubiquitin C-terminal hydrolase L1
  ubiquitin like 4A
  ubiquitin specific peptidase 30
  valosin containing protein
  vesicle amine transport 1
  VGF nerve growth factor inducible
  vimentin
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  voltage dependent anion channel 3
  VPS35 retromer complex component
  X-ray repair cross complementing 5
  Y-box binding protein 3
  zinc finger CCCH-type containing 15
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.