TPM3, tropomyosin 3

TPM3, tropomyosin 3

• This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

• Gene Synonyms (tropomyosin alpha-3 chain, alpha-tropomyosin, slow skeletal, cytoskeletal tropomyosin TM30, epididymis luminal protein 189, epididymis secretory sperm binding protein Li 82p, heat-stable cytoskeletal protein 30 kDa, tropomyosin 3 nu, tropomyosin gamma, tropomyosin-5, CAPM1, CFTD, HEL-189, HEL-S-82p, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPM3nu, TPMsk3, TRK, hscp30,)
• NCBI Gene ID: 7170
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A087WWU8
  UNIPROT ID#>>P06753
  UNIPROT ID#>>B4DQ80
  UNIPROT ID#>>A0A0S2Z4I4
  UNIPROT ID#>>A0A0S2Z4G4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tropomyosin 3 interacts with:

• AAR2 splicing factor
  actin, beta
  adenosylhomocysteinase like 1
  agrin
  anillin actin binding protein
  anterior gradient 2, protein disulphide isomerase family member
  biogenesis of lysosomal organelles complex 1 subunit 6
  calcium binding and coiled-coil domain 1
  calmodulin-like 3
  caveolae associated protein 3
  cell division cycle 123
  chromosome 1 open reading frame 216
  coiled-coil alpha-helical rod protein 1
  coiled-coil domain containing 102B
  coiled-coil domain containing 114
  coiled-coil domain containing 146
  creatine kinase, mitochondrial 1A
  cullin 3
  cullin 7
  cyclase associated actin cytoskeleton regulatory protein 1
  cytochrome c oxidase subunit 5A
  DISC1 scaffold protein
  elongation factor Tu GTP binding domain containing 2
  family with sequence similarity 9 member C
  F-box protein 5
  HD domain containing 3
  histone deacetylase 4
  histone deacetylase 8
  hook microtubule tethering protein 2
  hook microtubule tethering protein 3
  IKBKB interacting protein
  IMP U3 small nucleolar ribonucleoprotein 3
  integrin alpha 5 (fibronectin receptor alpha)
  IQ motif containing GTPase activating protein 1
  KxDL motif containing 1
  kynureninase
  lebercilin LCA5 like
  leucine rich adaptor protein 1
  leucine rich repeat kinase 2
  leucyl-tRNA synthetase 1
  lysine demethylase 6B
  MAGE family member D2
  mediator of DNA damage checkpoint 1
  methyltransferase like 14
  methyltransferase like 2B
  MIS12 kinetochore complex component
  mitochondrial carrier 1
  mitotic arrest deficient 1 like 1
  myosin heavy chain 7B
  myosin VC
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  nucleoporin 54
  nucleotide binding oligomerization domain containing 2
  obscurin like cytoskeletal adaptor 1
  O-GlcNAcase
  Opa interacting protein 5
  osteoclast stimulating factor 1
  Parkinsonism associated deglycase
  PAX interacting protein 1
  PDZ and LIM domain 7
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  pleckstrin homology like domain family B member 3
  poly(A) specific ribonuclease subunit PAN2
  RAD18 E3 ubiquitin protein ligase
  regulatory associated protein of MTOR complex 1
  ring finger protein 181
  ring finger protein 20
  SAGA complex associated factor 29
  SEC23 interacting protein
  septin 9
  small ubiquitin like modifier 4
  SNAP associated protein
  sperm associated antigen 9
  splicing factor 3a subunit 2
  synaptonemal complex central element protein 1
  TCF3 fusion partner
  testis specific serine kinase substrate
  tet methylcytosine dioxygenase 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  THAP domain containing 1
  THAP domain containing 7
  THO complex 1
  thyroid hormone receptor interactor 6
  TNF receptor associated protein 1
  tousled like kinase 1
  tropomodulin 2
  tropomyosin 1, alpha
  tropomyosin 3
  tropomyosin 4
  tropomyosin 4
  ubiquinol-cytochrome c reductase core protein 2
  vacuole membrane protein 1
  voltage dependent anion channel 1
  WASH complex subunit 1
  WT1 associated protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.