TRAF3, TNF receptor associated factor 3

TRAF3, TNF receptor associated factor 3

• The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]

• Gene Synonyms (TNF receptor-associated factor 3, CD40 associated protein 1, CD40 binding protein, CD40 receptor associated factor 1, LMP1-associated protein 1, RING-type E3 ubiquitin transferase TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, RNF118,)
• NCBI Gene ID: 7187
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A6NHG8
  UNIPROT ID#>>Q13114
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF receptor associated factor 3 interacts with:

• 5-azacytidine induced 2
  activating signal cointegrator 1 complex subunit 1
  apolipoprotein B mRNA editing enzyme catalytic subunit 3C
  basic, immunoglobulin-like variable motif containing
  brain expressed X-linked 3
  calcium binding and coiled-coil domain 2
  CASP8 and FADD like apoptosis regulator
  cell division cycle 37, HSP90 cochaperone
  chromosome 10 open reading frame 62
  coiled-coil domain containing 13
  coiled-coil domain containing 184
  CUGBP Elav-like family member 2
  DDB1 and CUL4 associated factor 7
  DExH-box helicase 58
  ectodysplasin A receptor
  ectodysplasin A2 receptor
  family with sequence similarity 53 member C
  FOS like 1, AP-1 transcription factor subunit
  glucocorticoid modulatory element binding protein 2
  heat shock protein family B (small) member 11
  hemogen
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  inositol hexakisphosphate kinase 3
  interleukin 17 receptor A
  ligand of numb-protein X 1
  mitochondrial antiviral signaling protein
  mitogen-activated protein kinase kinase kinase 14
  NLR family member X1
  NmrA like redox sensor 1
  N-terminal glutamine amidase 1
  nuclear factor of activated T cells 2 interacting protein
  nucleoporin 62
  optineurin
  OTU deubiquitinase 5
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  PDZ and LIM domain 7
  PDZ domain containing 4
  POM121 transmembrane nucleoporin
  protein inhibitor of activated STAT 2
  PTEN induced kinase 1
  RAS related 2
  receptor interacting serine/threonine kinase 1
  receptor interacting serine/threonine kinase 2
  ring finger protein 166
  ring finger protein 216
  ripply transcriptional repressor 1
  RNA binding motif protein 14
  SEC16 homolog A, endoplasmic reticulum export factor
  secretion associated Ras related GTPase 1A
  sedoheptulokinase
  serine/threonine kinase 38
  SHANK associated RH domain interactor
  SMAD specific E3 ubiquitin protein ligase 1
  stimulator of interferon response cGAMP interactor 1
  synaptosome associated protein 29
  TANK binding kinase 1
  Tax1 binding protein 1
  testis specific serine kinase substrate
  TNF receptor associated factor 3
  TNF receptor associated factor 5
  TNF receptor superfamily member 11a
  TNF receptor superfamily member 12A
  TNF receptor superfamily member 13B
  TNF receptor superfamily member 13C
  TNF receptor superfamily member 14
  TNF receptor superfamily member 18
  TNF receptor superfamily member 19
  TNF receptor superfamily member 4
  TNF superfamily member 14
  TNFAIP3 interacting protein 1
  TNFRSF1A associated via death domain
  toll like receptor 9
  toll like receptor adaptor molecule 1
  TRAF family member associated NFKB activator
  TRAF interacting protein
  TRAF3 interacting protein 1
  TRAF3 interacting protein 2
  TRAF3 interacting protein 3
  trafficking from ER to golgi regulator
  tripartite motif containing 14
  trophinin associated protein
  tumor necrosis factor receptor superfamily, member 12a
  tyrosyl-DNA phosphodiesterase 2
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 O
  ubiquitin C-terminal hydrolase L1
  ubiquitin specific peptidase 1
  ubiquitin specific peptidase 17 like family member 2
  ubiquitin specific peptidase 25
  ubiquitin specific peptidase 7
  USO1 vesicle transport factor
  vav guanine nucleotide exchange factor 3
  vir like m6A methyltransferase associated
  WD repeat domain 5
  WD repeat domain 82
  Z-DNA binding protein 1
  zinc finger and BTB domain containing 49
  zinc finger and SCAN domain containing 4
  zinc finger CCCH-type containing 12A
  zinc finger MYND-type containing 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.