PFN1, profilin 1

PFN1, profilin 1

• This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]

• Gene Synonyms (profilin-1, epididymis tissue protein Li 184a, profilin I, ALS18,)
• NCBI Gene ID: 5216
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P07737
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

profilin 1 interacts with:

• A kinase (PRKA) anchor protein (gravin) 12
  AAR2 splicing factor
  acetyl-CoA acyltransferase 2
  actin, beta
  amyloid beta precursor protein binding family B member 1 interacting protein
  ankyrin repeat and SOCS box containing 1
  ankyrin repeat and SOCS box containing 12
  ankyrin repeat and SOCS box containing 2
  anterior gradient 2, protein disulphide isomerase family member
  autophagy related 16 like 1
  casein kinase 1, epsilon
  cell division cycle 73
  cullin 3
  cullin 7
  cullin associated and neddylation dissociated 1
  DAZ associated protein 1
  decapping enzyme, scavenger
  discs large MAGUK scaffold protein 5
  dynamin 1 like
  ENAH actin regulator
  ergosterol biosynthesis 28 homolog
  exportin 6
  expressed sequence AI837181
  flotillin 1
  gephyrin
  HEXIM P-TEFb complex subunit 1
  ISG15 ubiquitin like modifier
  La ribonucleoprotein 7, transcriptional regulator
  ligand dependent nuclear receptor interacting factor 1
  microtubule associated serine/threonine kinase 3
  mitochondrial ribosomal protein L53
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase 3
  Myb related transcription factor, partner of profilin
  NHL repeat containing 2
  nuclear receptor subfamily 2 group C member 2
  obscurin like cytoskeletal adaptor 1
  phosphatase and tensin homolog
  phosphoethanolamine/phosphocholine phosphatase 1
  phosphoinositide-3-kinase regulatory subunit 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  PTEN induced kinase 1
  RAD51 recombinase
  RAD52 homolog, DNA repair protein
  ras homolog family member Q
  RecQ like helicase 4
  ring finger protein 123
  SET nuclear proto-oncogene
  signal regulatory protein alpha
  solute carrier family 33 member 1
  SRP receptor subunit beta
  SRSF protein kinase 1
  sterol O-acyltransferase 1
  STIP1 homology and U-box containing protein 1
  superoxide dismutase 1
  suppressor of cytokine signaling 1
  thymosin beta 10
  TLE family member 1, transcriptional corepressor
  TNF receptor associated factor 6
  TNFAIP3 interacting protein 2
  tripartite motif containing 15
  tripartite motif containing 25
  tumor protein p63
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin conjugating enzyme E2 A
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  unc-119 lipid binding chaperone
  vascular cell adhesion molecule 1
  vasoactive intestinal peptide receptor 1
  vasodilator stimulated phosphoprotein
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  WAS/WASL interacting protein family member 2
  WASP family member 1
  WASP like actin nucleation promoting factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.