MCL1, MCL1 apoptosis regulator, BCL2 family member

MCL1, MCL1 apoptosis regulator, BCL2 family member

• This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

• Gene Synonyms (BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, induced myeloid leukemia cell differentiation protein Mcl-1, BCL2 family apoptosis regulator, MCL1, BCL2 family apoptosis regulator, bcl-2-like protein 3, bcl-2-related protein EAT/mcl1, myeloid cell leukemia 1, myeloid cell leukemia ES, myeloid cell leukemia sequence 1 (BCL2-related),)
• NCBI Gene ID: 4170
• Species: Homo sapiens (Human)
• UNIPROT ID#>>C8YZ26
  UNIPROT ID#>>Q07820
  UNIPROT ID#>>A0A087WT64
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MCL1 apoptosis regulator, BCL2 family member interacts with:

• argonaute RISC catalytic component 2
  aspartic peptidase retroviral like 1
  autophagy related 12
  BAG cochaperone 3
  BAG cochaperone 4
  BAG cochaperone 6
  BCL2 binding component 3
  BCL2 like 11
  Bcl2 modifying factor
  BCL2-associated X protein
  BCL2-like 11 (apoptosis facilitator)
  beclin 1
  beta-transducin repeat containing E3 ubiquitin protein ligase
  complement component 5a receptor 2
  cullin 1
  DOT1 like histone lysine methyltransferase
  dual specificity phosphatase 22
  egl-9 family hypoxia inducible factor 3
  ER degradation enhancing alpha-mannosidase like protein 2
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 7
  F-box protein 4
  harakiri, BCL2 interacting protein
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  immediate early response 3
  MCL1 apoptosis regulator, BCL2 family member
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 10
  MLLT11 transcription factor 7 cofactor
  MYC proto-oncogene, bHLH transcription factor
  NRAS proto-oncogene, GTPase
  NSFL1 cofactor
  nuclear RNA export factor 1
  OTU deubiquitinase 1
  parkin RBR E3 ubiquitin protein ligase
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  phorbol-12-myristate-13-acetate-induced protein 1
  phosphatidylethanolamine binding protein 1
  proliferating cell nuclear antigen
  protein kinase AMP-activated catalytic subunit alpha 1
  protein kinase AMP-activated non-catalytic subunit beta 1
  protein kinase AMP-activated non-catalytic subunit beta 2
  protein kinase AMP-activated non-catalytic subunit gamma 1
  protein kinase cAMP-dependent type I regulatory subunit alpha
  PTEN induced kinase 1
  pyruvate dehydrogenase kinase 2
  RAN binding protein 6
  RNA binding motif protein 10
  serpin family B member 7
  S-phase kinase associated protein 1
  StAR related lipid transfer domain containing 9
  syntaxin 8
  tankyrase
  taxilin gamma
  TNF receptor associated factor 6
  tripartite motif containing 11
  tumor protein p53
  tumor protein, translationally-controlled 1
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 13
  ubiquitin specific peptidase 17 like family member 2
  ubiquitin specific peptidase 9 X-linked
  UBX domain protein 6
  unk zinc finger
  voltage dependent anion channel 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.