MID1, midline 1

MID1, midline 1

• The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

• Gene Synonyms (BBBG1, FXY, GBBB1, MIDIN, OGS1, OS, OSX, RNF59, TRIM18, XPRF, ZNFXY, E3 ubiquitin-protein ligase Midline-1, Opitz/BBB syndrome, RING finger protein 59, RING finger protein Midline-1, RING-type E3 ubiquitin transferase Midline-1, midline 1 RING finger protein, putative transcription factor XPRF, tripartite motif protein TRIM18, tripartite motif-containing protein 18, zinc finger on X and Y, mouse, homolog of,)
• NCBI Gene ID: 4281
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A087X255
  UNIPROT ID#>>O15344
  UNIPROT ID#>>A0A024RBV4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

midline 1 interacts with:

• cell division cycle 37, HSP90 cochaperone
  dual specificity tyrosine phosphorylation regulated kinase 4
  elongation factor like GTPase 1
  elongin A
  epsin 2
  epsin 3
  family with sequence similarity 167 member A
  family with sequence similarity 50 member B
  geminin DNA replication inhibitor
  germ cell-less 1, spermatogenesis associated
  high mobility group 20B
  high mobility group 20B
  immunoglobulin (CD79A) binding protein 1
  kinesin family member 9
  leucine rich repeat containing 4
  ligand of numb-protein X 1
  MID1 interacting protein 1
  midline 1
  midline 2
  MLLT6, PHD finger containing
  NEDD4 binding protein 1
  nucleophosmin 1
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  paired box 6
  pentatricopeptide repeat domain 2
  polynucleotide kinase 3'-phosphatase
  proteasome 20S subunit alpha 1
  proteasome 20S subunit alpha 6
  proteasome 20S subunit beta 1
  proteasome 20S subunit beta 4
  proteasome 20S subunit beta 5
  proteasome 20S subunit beta 6
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 7
  protein kinase N1
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 2 catalytic subunit beta
  protein phosphatase 2 phosphatase activator
  protein phosphatase 2 scaffold subunit Aalpha
  receptor for activated C kinase 1
  ribosomal protein S3
  ribosomal protein S8
  serine/threonine kinase 36
  sperm associated antigen 5
  starch binding domain 1
  transcription elongation factor A N-terminal and central domain containing
  tubulin alpha 1b
  tubulin beta 4B class IVb
  tubulin beta class I
  ubiquitin C
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 E1
  ubiquitin conjugating enzyme E2 E2
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 L6
  ubiquitin conjugating enzyme E2 N
  ubiquitin conjugating enzyme E2 V1
  ubiquitin conjugating enzyme E2 W
  ubiquitin domain containing 1
  vir like m6A methyltransferase associated
  zinc finger and BTB domain containing 42
  zinc finger FYVE-type containing 1
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 618

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.