NTRK3, neurotrophic receptor tyrosine kinase 3

NTRK3, neurotrophic receptor tyrosine kinase 3

• This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

• Gene Synonyms (GP145-TrkC, TRKC, gp145(trkC), NT-3 growth factor receptor, ETS related protein-neurotrophic receptor tyrosine kinase fusion protein, ETV6-NTRK3 fusion, neurotrophic tyrosine kinase, receptor, type 3, tyrosine kinase receptor C,)
• NCBI Gene ID: 4916
• Species: Homo sapiens (Human)
• UNIPROT ID#>>X5D7M5
  UNIPROT ID#>>B7Z7U4
  UNIPROT ID#>>X5D2R1
  UNIPROT ID#>>Q16288
  UNIPROT ID#>>O95193
  UNIPROT ID#>>X5DNW6
  UNIPROT ID#>>Q96CY4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

neurotrophic receptor tyrosine kinase 3 interacts with:

• acyl-CoA dehydrogenase family member 10
  brain expressed X-linked 3
  chromosome 6 open reading frame 120
  core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
  C-X-C motif chemokine receptor 4
  DENN domain containing 4A
  docking protein 5
  dynein light chain LC8-type 1
  EFR3 homolog A
  EH domain containing 4
  family with sequence similarity 171 member A2
  fibroblast growth factor receptor substrate 2
  G protein subunit beta 4
  HEAT repeat containing 6
  hes related family bHLH transcription factor with YRPW motif 1
  integrator complex subunit 7
  interleukin 1 receptor associated kinase 3
  kinase D interacting substrate 220
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  myeloid associated differentiation marker
  Nedd4 family interacting protein 1
  negative elongation factor complex member B
  nuclear receptor binding SET domain protein 1
  pentatricopeptide repeat domain 2
  phospholipase C gamma 1
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  protein only RNase P catalytic subunit
  protein tyrosine phosphatase non-receptor type 1
  protein tyrosine phosphatase receptor type S
  Ras protein specific guanine nucleotide releasing factor 1
  regulatory associated protein of MTOR complex 1
  sequestosome 1
  SH3 domain binding protein 4
  SHC adaptor protein 1
  SHC adaptor protein 2
  solute carrier family 39 member 11
  TBC1 domain family member 24
  transmembrane protein 11
  transmembrane protein 192
  tyrosine kinase non receptor 2
  WD repeat domain 13

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.