PIP4K2A, phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

PIP4K2A, phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

• Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]

• Gene Synonyms (phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, 1-phosphatidylinositol-4-phosphate kinase, 1-phosphatidylinositol-4-phosphate-5-kinase, PI(5)P 4-kinase type II alpha, PIP4KII-alpha, PIP5KIII, PIP5KIIalpha, PtdIns(4)P-5-kinase B isoform, diphosphoinositide kinase 2-alpha, phosphatidylinositol 5-phosphate 4-kinase type II alpha, phosphatidylinositol-4-phosphate 5-kinase, type II, alpha, ptdIns(4)P-5-kinase C isoform, ptdIns(5)P-4-kinase isoform 2-alpha, type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform, PI5P4KA, PIP5K2A, PIP5KII-alpha, PIP5KIIA, PIPK,)
• NCBI Gene ID: 5305
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P48426
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphatidylinositol-5-phosphate 4-kinase type 2 alpha interacts with:

• adaptor related protein complex 3 subunit beta 1
  adaptor related protein complex 3 subunit mu 1
  adenosylhomocysteinase like 1
  adenosylhomocysteinase like 2
  ADP ribosylation factor like GTPase 6 interacting protein 4
  AF4/FMR2 family member 4
  apoptotic chromatin condensation inducer 1
  bromodomain and PHD finger containing 1
  bromodomain containing 2
  bromodomain containing 3
  bromodomain containing 4
  calcium binding protein 39
  chromodomain helicase DNA binding protein 8
  chromodomain helicase DNA binding protein 9
  chromosome 12 open reading frame 43
  chromosome 18 open reading frame 25
  CLK4 associating serine/arginine rich protein
  coiled-coil domain containing 102A
  coiled-coil domain containing 9
  CWC22 spliceosome associated protein homolog
  CXXC finger protein 1
  DEAD-box helicase 23
  disco interacting protein 2 homolog C
  DnaJ heat shock protein family (Hsp40) member C13
  ELL associated factor 1
  ELL associated factor 2
  elongation factor for RNA polymerase II
  elongation factor for RNA polymerase II 2
  elongation factor for RNA polymerase II 3
  enhancer of mRNA decapping 4
  erythrocyte membrane protein band 4.1 like 3
  erythrocyte membrane protein band 4.1 like 5
  GC-rich promoter binding protein 1 like 1
  glutathione S-transferase kappa 1
  GPALPP motifs containing 1
  G-patch domain containing 8
  HDGF like 2
  interacts with SUPT6H, CTD assembly factor 1
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  KN motif and ankyrin repeat domains 1
  leucine zipper tumor suppressor 2
  leukocyte receptor cluster member 8
  mediator complex subunit 4
  Meis homeobox 3
  mex-3 RNA binding family member B
  mex-3 RNA binding family member C
  myotrophin
  myotubularin related protein 1
  NFKB activating protein
  nitric oxide synthase 1 adaptor protein
  nuclear assembly factor 1 ribonucleoprotein
  nuclear envelope integral membrane protein 1
  nuclear receptor subfamily 2 group C member 2
  nucleolar and coiled-body phosphoprotein 1
  patched 1
  peptidylprolyl isomerase G
  phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
  phosphatidylinositol-5-phosphate 4-kinase type 2 beta
  phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
  phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
  phospholipase C delta 3
  pinin, desmosome associated protein
  PNN interacting serine and arginine rich protein
  PPARG related coactivator 1
  pre-mRNA processing factor 8
  RAB11 family interacting protein 1
  RAB4A, member RAS oncogene family
  Rac family small GTPase 1
  RAD18 E3 ubiquitin protein ligase
  Rho GTPase activating protein 22
  ribosomal protein S6 kinase B1
  ring finger and WD repeat domain 3
  RNA binding protein with serine rich domain 1
  RTF1 homolog, Paf1/RNA polymerase II complex component
  Sad1 and UNC84 domain containing 2
  selenoprotein H
  serine and arginine rich splicing factor 8
  serine/arginine repetitive matrix 2
  serine/threonine kinase 11
  SET binding factor 1
  SET domain containing 1B, histone lysine methyltransferase
  SET domain containing 2, histone lysine methyltransferase
  spen family transcriptional repressor
  S-phase kinase associated protein 1
  ST6 beta-galactoside alpha-2,6-sialyltransferase 1
  STE20 related adaptor alpha
  STE20 related adaptor beta
  tec protein tyrosine kinase
  treacle ribosome biogenesis factor 1
  upstream binding transcription factor
  WD repeat domain 26
  zinc finger protein 428
  zinc finger RANBP2-type containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.