CTLA4, cytotoxic T-lymphocyte associated protein 4

CTLA4, cytotoxic T-lymphocyte associated protein 4

• This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

• Gene Synonyms (cytotoxic T-lymphocyte protein 4, CD152 isoform, celiac disease 3, cytotoxic T lymphocyte associated antigen 4 short spliced form, cytotoxic T-lymphocyte-associated serine esterase-4, insulin-dependent diabetes mellitus 12, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12,)
• NCBI Gene ID: 1493
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P16410
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cytotoxic T-lymphocyte associated protein 4 interacts with:

• adaptor related protein complex 1 subunit mu 1
  cortexin 3
  cytotoxic T-lymphocyte associated protein 4
  ELAV like RNA binding protein 1
  FYN proto-oncogene, Src family tyrosine kinase
  Janus kinase 2
  LCK proto-oncogene, Src family tyrosine kinase
  LYN proto-oncogene, Src family tyrosine kinase
  mal, T cell differentiation protein like
  phosphoinositide-3-kinase regulatory subunit 1
  protein phosphatase 2 regulatory subunit B'alpha
  protein tyrosine phosphatase non-receptor type 11
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  transmembrane protein 218
  TXK tyrosine kinase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.