DPH2, diphthamide biosynthesis 2

DPH2, diphthamide biosynthesis 2

• This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

• Gene Synonyms (DPH2L2, 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2, DPH2 homolog, DPH2-like 2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2, diphthamide biosynthesis protein 2 homolog-like 2, diphthamide biosynthesis-like protein 2, diphtheria toxin resistance protein 2, diptheria toxin resistance protein required for diphthamide biosynthesis-like 2,)
• NCBI Gene ID: 1802
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BQC3
  UNIPROT ID#>>B3KRB8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

diphthamide biosynthesis 2 interacts with:

• BAG cochaperone 3
  collectin subfamily member 12
  cyclase associated actin cytoskeleton regulatory protein 1
  dihydropyrimidinase like 2
  diphthamide biosynthesis 3
  eukaryotic translation elongation factor 2
  family with sequence similarity 219 member B
  farnesyl diphosphate synthase
  heat shock protein family A (Hsp70) member 8
  HSPA (Hsp70) binding protein 1
  interleukin 17A
  mago homolog, exon junction complex subunit
  mitotic spindle positioning
  MMS19 homolog, cytosolic iron-sulfur assembly component
  NIMA related kinase 6
  phenylalanyl-tRNA synthetase 2, mitochondrial
  regulation of nuclear pre-mRNA domain containing 1A
  regulator of G protein signaling 20
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding fox-1 homolog 2
  small nuclear ribonucleoprotein 13
  sulfotransferase family 4A member 1
  tumor susceptibility 101
  tyrosine kinase non receptor 2
  WD repeat domain, phosphoinositide interacting 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.