DPYSL2, dihydropyrimidinase like 2

DPYSL2, dihydropyrimidinase like 2

• This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

• Gene Synonyms (CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2, dihydropyrimidinase-related protein 2, collapsin response mediator protein hCRMP-2, unc-33-like phosphoprotein 2,)
• NCBI Gene ID: 1808
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q16555
  UNIPROT ID#>>A0A1C7CYX9
  UNIPROT ID#>>Q59GB4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dihydropyrimidinase like 2 interacts with:

• ADP ribosylation factor interacting protein 1
  armadillo repeat containing 1
  BICD cargo adaptor 2
  cell division cycle associated 8
  cyclase associated actin cytoskeleton regulatory protein 1
  dihydropyrimidinase like 2
  dihydropyrimidinase like 3
  dihydropyrimidinase like 4
  dihydropyrimidinase like 5
  DISC1 scaffold protein
  DnaJ heat shock protein family (Hsp40) member B1
  dual specificity tyrosine phosphorylation regulated kinase 1A
  dynein axonemal assembly factor 2
  ELAV like RNA binding protein 1
  eukaryotic translation initiation factor 3 subunit J
  exportin 7
  G3BP stress granule assembly factor 1
  galectin 7
  glycogen synthase kinase 3 beta
  golgi reassembly stacking protein 2
  HCLS1 associated protein X-1
  heat shock protein family A (Hsp70) member 8
  heat shock protein family H (Hsp110) member 1
  heterogeneous nuclear ribonucleoprotein L
  histone deacetylase 2
  huntingtin
  IQ motif containing B1
  kelch domain containing 3
  keratin 17
  lymphoid enhancer binding factor 1
  lysophospholipase 1
  magnesium dependent phosphatase 1
  minichromosome maintenance complex component 2
  MYC proto-oncogene, bHLH transcription factor
  neurotrophic receptor tyrosine kinase 1
  NHL repeat containing 2
  ninein
  N-terminal Xaa-Pro-Lys N-methyltransferase 1
  nuclear FMR1 interacting protein 1
  NUMB endocytic adaptor protein
  peroxiredoxin 2
  phosphodiesterase 3A
  phospholipase D2
  pleckstrin homology domain containing A4
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit gamma
  pseudouridine synthase 7
  RAN binding protein 6
  Rho associated coiled-coil containing protein kinase 1
  ribosomal RNA processing 7 homolog A
  ring finger protein 123
  sirtuin 7
  spindle apparatus coiled-coil protein 1
  TAFA chemokine like family member 3
  testis expressed 101
  TGFB induced factor homeobox 2 like Y-linked
  TRAF2 and NCK interacting kinase
  tripartite motif containing 14
  tubulin alpha 1a
  tubulin beta class I
  tumor susceptibility 101
  ubiquitin conjugating enzyme E2 I
  unc-13 homolog D
  unk zinc finger
  vir like m6A methyltransferase associated
  VPS28 subunit of ESCRT-I
  WD repeat domain 83
  WW domain containing E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.