FCGR3A, Fc fragment of IgG receptor IIIa

FCGR3A, Fc fragment of IgG receptor IIIa

• This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20, low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc fragment of IgG, low affinity III, receptor for (CD16), Fc fragment of IgG, low affinity IIIa, receptor (CD16a), Fc gamma receptor III-A, Fc-gamma RIII-alpha, Fc-gamma receptor III-2 (CD 16), Fc-gamma receptor IIIb (CD16), FcgammaRIIIA, igG Fc receptor III-2, immunoglobulin G Fc receptor III, low affinity immunoglobulin gamma receptor III-a Fc fragment, neutrophil-specific antigen NA,)
• NCBI Gene ID: 2214
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P08637
  UNIPROT ID#>>M9MML0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Fc fragment of IgG receptor IIIa interacts with:

• Fc fragment of IgG receptor IIIb
  glycerol kinase
  glycoprotein VI platelet
  latexin
  LCK proto-oncogene, Src family tyrosine kinase
  neuronal calcium sensor 1
  protein kinase C alpha
  protein kinase C iota
  protein tyrosine phosphatase receptor type C
  RAB32, member RAS oncogene family
  ring finger protein 40
  S100 calcium binding protein A4
  SHC adaptor protein 1
  spleen associated tyrosine kinase
  zeta chain of T cell receptor associated protein kinase 70
  zinc finger and BTB domain containing 25

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.