FHL1, four and a half LIM domains 1

FHL1, four and a half LIM domains 1

• This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]

• Gene Synonyms (FCMSU, FHL-1, FHL1A, FHL1B, FLH1A, KYOT, RBMX1A, RBMX1B, SLIM, SLIM-1, SLIM1, SLIMMER, XMPMA, four and a half LIM domains protein 1, LIM protein SLIMMER, four-and-a-half Lin11, Isl-1 and Mec-3 domains 1, skeletal muscle LIM-protein 1,)
• NCBI Gene ID: 2273
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13642
  UNIPROT ID#>>Q5JXI2
  UNIPROT ID#>>B7Z9A1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

four and a half LIM domains 1 interacts with:

• agrin
  A-kinase anchoring protein 12
  BCL2 associated transcription factor 1
  BICD cargo adaptor 2
  checkpoint kinase 2
  chromobox 4
  DEAF1 transcription factor
  developmental pluripotency-associated 3
  embryonic ectoderm development
  fermitin family member 2
  four and a half LIM domains 2
  G protein subunit beta 1
  G3BP stress granule assembly factor 1
  hes family bHLH transcription factor 1
  HIVEP zinc finger 3
  hypoxia inducible factor 1 subunit alpha
  lamin A/C
  mediator of DNA damage checkpoint 1
  myosin binding protein C1
  nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
  nuclear receptor interacting protein 1
  phosphodiesterase 4D interacting protein
  pleckstrin homology and RhoGEF domain containing G2
  pleckstrin homology domain containing A4
  potassium voltage-gated channel subfamily A member 5
  prion protein
  RE1 silencing transcription factor
  recombination signal binding protein for immunoglobulin kappa J region
  ring finger protein 1
  serum response factor
  SMAD family member 2
  SMAD family member 3
  SMAD family member 4
  SMAD specific E3 ubiquitin protein ligase 1
  Sp1 transcription factor
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRSF protein kinase 1
  stratifin
  thioredoxin interacting protein
  titin
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  ubiquitin C
  ubiquitin specific peptidase 15
  X-ray repair cross complementing 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.