RBPJ, recombination signal binding protein for immunoglobulin kappa J region

RBPJ, recombination signal binding protein for immunoglobulin kappa J region

• The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

• Gene Synonyms (recombining binding protein suppressor of hairless, H-2K binding factor-2, immunoglobulin kappa J region recombination signal binding protein 1, renal carcinoma antigen NY-REN-30, suppressor of hairless homolog, AOS3, CBF-1, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBP-J kappa, RBP-JK, RBPJK, RBPSUH, SUH, csl,)
• NCBI Gene ID: 3516
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q06330
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

recombination signal binding protein for immunoglobulin kappa J region interacts with:

• activity dependent neuroprotector homeobox
  ALX homeobox 4
  AT-rich interaction domain 3B
  BCL6B transcription repressor
  calmodulin regulated spectrin associated protein 1
  CGG triplet repeat binding protein 1
  chromatin assembly factor 1 subunit B
  corepressor interacting with RBPJ, CIR1
  craniofacial development protein 1
  cullin 1
  DDB1 and CUL4 associated factor 16
  DEAD-box helicase 24
  DEK proto-oncogene
  exportin 1
  F-box protein 42
  formin binding protein 1
  formin binding protein 1 like
  GATA zinc finger domain containing 2A
  general transcription factor IIIC subunit 4
  general transcription factor IIIC subunit 5
  H4 clustered histone 1
  high mobility group 20B
  jumonji domain containing 1C
  kinesin family member 2C
  L3MBTL histone methyl-lysine binding protein 3
  ligand dependent nuclear receptor corepressor
  lysine acetyltransferase 2B
  lysine acetyltransferase 5
  lysine demethylase 1A
  lysine demethylase 2A
  lysine demethylase 5A
  macroH2A.1 histone
  MAP7 domain containing 3
  mastermind like transcriptional coactivator 1
  mastermind like transcriptional coactivator 2
  mastermind like transcriptional coactivator 3
  mediator complex subunit 23
  mediator complex subunit 27
  methyl-CpG binding domain protein 1
  methyl-CpG binding domain protein 2
  methyl-CpG binding protein 2
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 7
  NK6 homeobox 1
  NMDA receptor synaptonuclear signaling and neuronal migration factor
  notch 1
  notch receptor 1
  notch receptor 2
  notch receptor 3
  notch receptor 4
  nuclear factor I A
  nuclear factor I C
  nuclear factor I X
  nuclear factor of activated T cells 1
  nuclear receptor corepressor 1
  nuclear receptor corepressor 2
  nuclear receptor subfamily 2 group F member 2
  nucleus accumbens associated 1
  O-linked N-acetylglucosamine (GlcNAc) transferase
  paired like homeodomain 2
  pancreas associated transcription factor 1a
  PBX homeobox 1
  PC4 and SFRS1 interacting protein 1
  PHD finger protein 21A
  PHD finger protein 8
  POP1 homolog, ribonuclease P/MRP subunit
  POZ/BTB and AT hook containing zinc finger 1
  Ran GTPase activating protein 1
  RBPJ interacting and tubulin associated 1
  RecQ like helicase
  replication protein A2
  ribosomal protein S6 kinase A6
  ring finger protein 20
  SATB homeobox 1
  SATB homeobox 2
  Scm like with four mbt domains 1
  Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
  SIN3 transcription regulator family member A
  SNW domain containing 1
  speckle type BTB/POZ protein
  spen family transcriptional repressor
  spliceosome associated factor 3, U4/U6 recycling protein
  staphylococcal nuclease and tudor domain containing 1
  staufen double-stranded RNA binding protein 1
  sterile alpha motif domain containing 1
  SUFU negative regulator of hedgehog signaling
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  TARBP2 subunit of RISC loading complex
  TATA-box binding protein
  thioredoxin domain containing 5
  TPX2 microtubule nucleation factor
  transcription factor AP-4
  tropomyosin 1
  tropomyosin 2
  tumor protein p53
  ubiquitin specific peptidase 47
  ubiquitin specific peptidase 7
  WD repeat domain 70
  zinc finger and BTB domain containing 10
  zinc finger MIZ-type containing 1
  zinc finger protein 143
  zinc finger protein 268
  zinc finger protein 589

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.