RAB3GAP1, RAB3 GTPase activating protein catalytic subunit 1

RAB3GAP1, RAB3 GTPase activating protein catalytic subunit 1

• This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

• Gene Synonyms (P130, RAB3GAP, RAB3GAP130, WARBM1, rab3 GTPase-activating protein catalytic subunit, RAB3 GTPase activating protein subunit 1 (catalytic), RAB3 GTPase-activating protein 130 kDa subunit, rab3-GAP p130,)
• NCBI Gene ID: 22930
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B9A6J2
  UNIPROT ID#>>Q15042
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RAB3 GTPase activating protein catalytic subunit 1 interacts with:

• chromosome 6 open reading frame 141
  DDB1 and CUL4 associated factor 15
  dedicator of cytokinesis 5
  Dmx like 2
  egl-9 family hypoxia inducible factor 3
  folliculin
  limb development membrane protein 1 like
  microtubule associated protein 1 light chain 3 alpha
  nuclear receptor coactivator 7
  OTU deubiquitinase with linear linkage specificity like
  PAX interacting protein 1
  RAB22A, member RAS oncogene family
  RAB3 GTPase activating non-catalytic protein subunit 2
  RAB39A, member RAS oncogene family
  RAB39B, member RAS oncogene family
  RCC1 domain containing 1
  sirtuin 2
  testin LIM domain protein
  tRNA splicing endonuclease subunit 34
  WD repeat domain 7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.