FLG, filaggrin

FLG, filaggrin

• The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]

• Gene Synonyms (ATOD2, filaggrin, epidermal filaggrin,)
• NCBI Gene ID: 2312
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P20930
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

filaggrin interacts with:

• cilia and flagella associated protein 298
  cullin 2
  FCF1 rRNA-processing protein
  ferritin heavy chain 1
  G protein-coupled receptor 18
  germ cell-less 1, spermatogenesis associated
  heterogeneous nuclear ribonucleoprotein A1
  histatin 3
  killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1
  La ribonucleoprotein 7, transcriptional regulator
  male germ cell associated kinase
  MCL1 apoptosis regulator, BCL2 family member
  methyltransferase like 14
  N-methylpurine DNA glycosylase
  phosphatidylinositol 4-kinase alpha
  proprotein convertase subtilisin/kexin type 6
  proteasome 26S subunit, non-ATPase 14
  PTEN induced kinase 1
  serine/threonine kinase 16
  TNF receptor superfamily member 19
  tubulin gamma 1
  ubiquitin C-terminal hydrolase L5
  ubiquitin specific peptidase 1
  uncoupling protein 2
  zinc finger and SCAN domain containing 12

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.