HNRNPA1, heterogeneous nuclear ribonucleoprotein A1

HNRNPA1, heterogeneous nuclear ribonucleoprotein A1

• This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016]

• Gene Synonyms (heterogeneous nuclear ribonucleoprotein A1, epididymis secretory sperm binding protein, helix-destabilizing protein, heterogeneous nuclear ribonucleoprotein A1B protein, heterogeneous nuclear ribonucleoprotein B2 protein, heterogeneous nuclear ribonucleoprotein core protein A1, hnRNP core protein A1-like 3, nuclear ribonucleoprotein particle A1 protein, putative heterogeneous nuclear ribonucleoprotein A1-like 3, single-strand DNA-binding protein UP1, single-strand RNA-binding protein, ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, UP 1, hnRNP A1, hnRNP-A1,)
• NCBI Gene ID: 3178
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P09651
  UNIPROT ID#>>A0A024RAZ7
  UNIPROT ID#>>A0A024RB53
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

heterogeneous nuclear ribonucleoprotein A1 interacts with:

• 5'-3' exoribonuclease 1
  5'-3' exoribonuclease 2
  AAR2 splicing factor
  abhydrolase domain containing 16A, phospholipase
  acetyl-CoA acyltransferase 2
  activator of HSP90 ATPase activity 1
  afadin, adherens junction formation factor
  agrin
  A-kinase anchoring protein 8
  aldo-keto reductase family 1 member B10
  alpha-2-macroglobulin like 1
  Aly/REF export factor
  aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
  angel homolog 2
  ankyrin repeat and SOCS box containing 2
  anterior gradient 2, protein disulphide isomerase family member
  apolipoprotein B mRNA editing enzyme catalytic subunit 3B
  apoptotic chromatin condensation inducer 1
  aquarius intron-binding spliceosomal factor
  ariadne RBR E3 ubiquitin protein ligase 2
  aspartic peptidase retroviral like 1
  AT-rich interaction domain 2
  aurora kinase A
  aurora kinase B
  autophagy related 16 like 1
  bromodomain containing 7
  calcium responsive transcription factor
  calmodulin like 5
  cap methyltransferase 1
  CDKN2A interacting protein
  cell cycle and apoptosis regulator 2
  cell cycle associated protein 1
  cell division cycle 37, HSP90 cochaperone
  chloride intracellular channel 4
  chromosome 1 open reading frame 68
  cleavage and polyadenylation specific factor 2
  cleavage and polyadenylation specific factor 6
  cleavage and polyadenylation specific factor 7
  coactivator associated arginine methyltransferase 1
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  creatine kinase, mitochondrial 1A
  cullin 1
  cullin 2
  cullin 3
  cullin 4B
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cytochrome b5 type B
  DEAD-box helicase 17
  DEAD-box helicase 23
  DEAD-box helicase 28
  DEAH-box helicase 36
  death associated protein 3
  defective in cullin neddylation 1 domain containing 1
  deoxynucleotidyltransferase terminal interacting protein 2
  dermcidin
  DExD-box helicase 21
  DExH-box helicase 30
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  DNA ligase 4
  DNA polymerase delta interacting protein 3
  DNA topoisomerase I
  DnaJ heat shock protein family (Hsp40) member C10
  dual specificity phosphatase 11
  Ecm29 proteasome adaptor and scaffold
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  epiplakin 1
  eukaryotic translation initiation factor 2B subunit gamma
  eukaryotic translation initiation factor 3 subunit H
  eukaryotic translation initiation factor 4A3
  exosome component 4
  exportin 1
  factor interacting with PAPOLA and CPSF1
  family with sequence similarity 120A
  family with sequence similarity 120C
  family with sequence similarity 98 member B
  far upstream element binding protein 3
  Fas associated factor 1
  FAST kinase domains 2
  F-box and WD repeat domain containing 11
  F-box protein 6
  FERM domain containing 4A
  filaggrin family member 2
  fused in sarcoma
  G3BP stress granule assembly factor 1
  G3BP stress granule assembly factor 2
  GADD45G interacting protein 1
  galectin 7
  gigaxonin
  glutaminyl-tRNA synthetase 1
  glycerophosphodiester phosphodiesterase 1
  H1.10 linker histone
  H2A clustered histone 4
  H3 clustered histone 1
  H3.4 histone
  H4 clustered histone 1
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 2
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  heat shock protein family B (small) member 1
  heat shock protein family D (Hsp60) member 1
  hes related family bHLH transcription factor with YRPW motif 1
  heterogeneous nuclear ribonucleoprotein A/B
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein A1 like 2
  heterogeneous nuclear ribonucleoprotein A2/B1
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein C
  heterogeneous nuclear ribonucleoprotein C like 2
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein H1
  heterogeneous nuclear ribonucleoprotein H2
  heterogeneous nuclear ribonucleoprotein H3
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein L
  heterogeneous nuclear ribonucleoprotein M
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U
  heterogeneous nuclear ribonucleoprotein U like 1
  heterogeneous nuclear ribonucleoprotein U like 2
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 6
  homeodomain interacting protein kinase 3
  hornerin
  immunoglobulin superfamily member 8
  influenza virus NS1A binding protein
  inosine triphosphatase
  insulin like growth factor 2 mRNA binding protein 1
  insulin like growth factor 2 mRNA binding protein 2
  insulin like growth factor 2 mRNA binding protein 3
  integrin alpha FG-GAP repeat containing 1
  integrin subunit alpha 4
  intercellular adhesion molecule 1
  interferon induced protein with tetratricopeptide repeats 2
  interferon induced protein with tetratricopeptide repeats 3
  interleukin 36 gamma
  interleukin enhancer binding factor 2
  interleukin enhancer binding factor 3
  involucrin
  IQ motif containing GTPase activating protein 1
  jun B proto-oncogene
  junction plakoglobin
  keratin 1
  keratin 10
  keratin 14
  keratin 15
  keratin 16
  keratin 17
  keratin 2
  keratin 33A
  keratin 34
  keratin 5
  keratin 6A
  keratin 6B
  keratin 6C
  keratin 78
  keratin 79
  keratin 80
  keratin 83
  keratin 9
  keratinocyte proline rich protein
  KH RNA binding domain containing, signal transduction associated 1
  KH RNA binding domain containing, signal transduction associated 2
  KH-type splicing regulatory protein
  kinase suppressor of ras 1
  La ribonucleoprotein 1, translational regulator
  La ribonucleoprotein 1B
  La ribonucleoprotein 7, transcriptional regulator
  lactate dehydrogenase A
  lamin A/C
  lamin B1
  leucine rich pentatricopeptide repeat containing
  lipocalin 2
  LTV1 ribosome biogenesis factor
  lysine acetyltransferase 8
  lysosomal associated membrane protein 1
  maelstrom spermatogenic transposon silencer
  malonyl-CoA-acyl carrier protein transacylase
  matrin 3
  MDM2 proto-oncogene
  metadherin
  metal regulatory transcription factor 1
  methylphosphate capping enzyme
  methyltransferase like 14
  minichromosome maintenance complex component 2
  minichromosome maintenance complex component 5
  mitochondrial assembly of ribosomal large subunit 1
  mitochondrial ribosomal protein L1
  mitochondrial ribosomal protein L10
  mitochondrial ribosomal protein L11
  mitochondrial ribosomal protein L13
  mitochondrial ribosomal protein L15
  mitochondrial ribosomal protein L16
  mitochondrial ribosomal protein L18
  mitochondrial ribosomal protein L19
  mitochondrial ribosomal protein L21
  mitochondrial ribosomal protein L22
  mitochondrial ribosomal protein L24
  mitochondrial ribosomal protein L27
  mitochondrial ribosomal protein L28
  mitochondrial ribosomal protein L3
  mitochondrial ribosomal protein L32
  mitochondrial ribosomal protein L35
  mitochondrial ribosomal protein L37
  mitochondrial ribosomal protein L38
  mitochondrial ribosomal protein L39
  mitochondrial ribosomal protein L4
  mitochondrial ribosomal protein L43
  mitochondrial ribosomal protein L44
  mitochondrial ribosomal protein L45
  mitochondrial ribosomal protein L46
  mitochondrial ribosomal protein L47
  mitochondrial ribosomal protein L48
  mitochondrial ribosomal protein L52
  mitochondrial ribosomal protein L57
  mitochondrial ribosomal protein L58
  mitochondrial ribosomal protein L9
  mitochondrial ribosomal protein S10
  mitochondrial ribosomal protein S15
  mitochondrial ribosomal protein S18A
  mitochondrial ribosomal protein S18B
  mitochondrial ribosomal protein S18C
  mitochondrial ribosomal protein S2
  mitochondrial ribosomal protein S22
  mitochondrial ribosomal protein S23
  mitochondrial ribosomal protein S24
  mitochondrial ribosomal protein S27
  mitochondrial ribosomal protein S28
  mitochondrial ribosomal protein S30
  mitochondrial ribosomal protein S31
  mitochondrial ribosomal protein S35
  mitochondrial ribosomal protein S5
  mitochondrial ribosomal protein S7
  mitochondrial ribosomal protein S9
  mitochondrial transcription termination factor 3
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase kinase 1
  moesin
  Mov10 RISC complex RNA helicase
  musashi RNA binding protein 2
  MX dynamin like GTPase 1
  MYC proto-oncogene, bHLH transcription factor
  myocyte enhancer factor 2A
  myosin heavy chain 9
  myosin light chain 12A
  NADH:ubiquinone oxidoreductase complex assembly factor 8
  NCCRP1, F-box associated domain containing
  NEDD1 gamma-tubulin ring complex targeting factor
  NEDD8 ubiquitin like modifier
  neugrin, neurite outgrowth associated
  neurobeachin like 1
  neurotrophic receptor tyrosine kinase 1
  NFKB inhibitor alpha
  NFKB repressing factor
  nicotinamide nucleotide transhydrogenase
  nicotinamide phosphoribosyltransferase
  nitric oxide synthase 2
  non-POU domain containing octamer binding
  NOP2/Sun RNA methyltransferase 5
  NOP56 ribonucleoprotein
  nuclear cap binding protein subunit 1
  nuclear factor of activated T cells 1
  nuclear factor of activated T cells 2
  nuclear receptor coactivator 5
  nuclear receptor subfamily 0 group B member 2
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  nuclear transcription factor, X-box binding 1
  nucleolin
  nucleoporin 205
  nudix hydrolase 21
  obscurin like cytoskeletal adaptor 1
  palmitoyl-protein thioesterase 1
  par-6 family cell polarity regulator beta
  parkin RBR E3 ubiquitin protein ligase
  partner of NOB1 homolog
  pentatricopeptide repeat domain 1
  pentatricopeptide repeat domain 3
  peptidylprolyl isomerase A
  peptidylprolyl isomerase E
  peptidylprolyl isomerase like 1
  periplakin
  peroxiredoxin 1
  PHD finger protein 5A
  phenylalanyl-tRNA synthetase 2, mitochondrial
  phosphatidylinositol binding clathrin assembly protein
  phosphoglycerate dehydrogenase
  phosphoglycerate kinase 1
  phytanoyl-CoA 2-hydroxylase interacting protein
  PIH1 domain containing 1
  pinin, desmosome associated protein
  plakophilin 1
  pleckstrin homology domain containing A4
  POF1B actin binding protein
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  poly(A) binding protein interacting protein 2
  poly(A) binding protein interacting protein 2B
  poly(A) binding protein nuclear 1
  poly(A) polymerase alpha
  poly(A) specific ribonuclease subunit PAN2
  poly(rC) binding protein 1
  poly(rC) binding protein 2
  poly(U) binding splicing factor 60
  polypyrimidine tract binding protein 1
  pre-mRNA processing factor 19
  pre-mRNA processing factor 31
  pre-mRNA processing factor 4
  pre-mRNA processing factor 8
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
  profilin 1
  programmed cell death 11
  programmed cell death 4
  prohibitin
  prohibitin 2
  proline rich coiled-coil 1
  proline rich coiled-coil 2A
  prolyl 4-hydroxylase subunit beta
  proteasome 20S subunit alpha 3
  proteasome 20S subunit beta 4
  proteasome 26S subunit, non-ATPase 9
  protein arginine methyltransferase 1
  protein arginine methyltransferase 2
  protein arginine methyltransferase 3
  protein arginine methyltransferase 8
  protein kinase C zeta
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 5 catalytic subunit
  prothymosin alpha
  PTEN induced kinase 1
  purine nucleoside phosphorylase
  purine rich element binding protein A
  pyridoxal phosphate binding protein
  pyruvate dehydrogenase E1 subunit alpha 1
  pyruvate kinase M1/2
  RAB1A, member RAS oncogene family
  RAD50 double strand break repair protein
  RALY heterogeneous nuclear ribonucleoprotein
  receptor for activated C kinase 1
  RecQ like helicase 4
  replication protein A1
  replication protein A2
  replication protein A3
  Rho associated coiled-coil containing protein kinase 1
  Rho GTPase activating protein 23
  ribosomal protein L21
  ribosomal protein L26
  ribosomal protein L27a
  ribosomal protein L38
  ribosomal protein lateral stalk subunit P2
  ribosomal protein S15
  ribosomal protein S15a
  ribosomal protein S21
  ribosomal protein S27a
  ribosomal protein S3
  ribosomal protein S3A
  ribosomal protein S5
  ribosomal protein S6
  ribosomal protein S6 kinase B2
  ribosomal protein S7
  ribosomal protein S8
  ribosomal protein SA
  ribosomal RNA processing 1 homolog B (S. cerevisiae)
  ribosomal RNA processing 1B
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 14
  ring finger protein 2
  ring finger protein 31
  ring finger protein 4
  RIO kinase 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 12
  RNA binding motif protein 12B
  RNA binding motif protein 14
  RNA binding motif protein 26
  RNA binding motif protein 3
  RNA binding motif protein 39
  RNA binding motif protein 6
  RNA binding motif protein 7
  RNA binding motif protein X-linked
  RNA binding motif single stranded interacting protein 1
  RNA polymerase II associated protein 1
  RNA pseudouridine synthase D3
  RNA transcription, translation and transport factor
  scaffold attachment factor B
  scaffold attachment factor B2
  SEC16 homolog A, endoplasmic reticulum export factor
  SEC31 homolog A, COPII coat complex component
  serine and arginine rich splicing factor 1
  serine and arginine rich splicing factor 4
  serine and arginine rich splicing factor 6
  serine and arginine rich splicing factor 7
  serine protease 3
  serine/arginine repetitive matrix 2
  serine/threonine kinase receptor associated protein
  serrate, RNA effector molecule
  shieldin complex subunit 2
  signal recognition particle 72
  Sin3A associated protein 25
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein D3 polypeptide
  small nuclear ribonucleoprotein U1 subunit 70
  small nuclear ribonucleoprotein U5 subunit 200
  small RNA binding exonuclease protection factor La
  snail family transcriptional repressor 1
  SNW domain containing 1
  spermatid perinuclear RNA binding protein
  spindle apparatus coiled-coil protein 1
  splicing factor 3a subunit 2
  splicing factor 3b subunit 6
  splicing factor proline and glutamine rich
  splicing regulatory glutamic acid and lysine rich protein 1
  SRSF protein kinase 1
  SRSF protein kinase 2
  staufen double-stranded RNA binding protein 1
  succinate dehydrogenase complex flavoprotein subunit A
  SUFU negative regulator of hedgehog signaling
  suppressor of cancer cell invasion
  SURP and G-patch domain containing 2
  survival of motor neuron 1, telomeric
  Suv3 like RNA helicase
  synaptotagmin binding cytoplasmic RNA interacting protein
  synaptotagmin like 2
  TAR DNA binding protein
  TATA-box binding protein associated factor 15
  TATA-box binding protein associated factor 15
  THAP domain containing 12
  thymopoietin
  TNF receptor associated factor 6
  TNFAIP3 interacting protein 2
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  transcription factor EC
  transcription termination factor 2
  transformer 2 beta homolog
  transportin 1
  tripartite motif containing 25
  TruB pseudouridine synthase family member 2
  tubulin gamma complex associated protein 3
  tumor necrosis factor
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  tyrosine kinase non receptor 1
  tyrosyl-tRNA synthetase 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  ubiquitin conjugating enzyme E2 I
  ubiquitin protein ligase E3 component n-recognin 1
  ubiquitin protein ligase E3 component n-recognin 2
  UPF1 RNA helicase and ATPase
  valosin containing protein
  vascular cell adhesion molecule 1
  von Hippel-Lindau tumor suppressor
  VRK serine/threonine kinase 1
  VRK serine/threonine kinase 3
  WD repeat domain 33
  WD repeat domain 77
  WD repeat domain 82
  WW domain containing E3 ubiquitin protein ligase 2
  XPA binding protein 2
  X-ray repair cross complementing 5
  Y-box binding protein 3
  Yes1 associated transcriptional regulator
  YLP motif containing 1
  YTH domain containing 1
  YTH N6-methyladenosine RNA binding protein 2
  YY1 associated factor 2
  zinc finger C3HC-type containing 1
  zinc finger CCHC-type containing 3
  zinc finger protein 326
  zinc finger protein 638
  zinc finger RNA binding protein
  ZW10 interacting kinetochore protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.