PRPF4, pre-mRNA processing factor 4

PRPF4, pre-mRNA processing factor 4

• The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

• Gene Synonyms (U4/U6 small nuclear ribonucleoprotein Prp4, PRP4 homolog, PRP4 pre-mRNA processing factor 4 homolog, PRP4/STK/WD splicing factor, U4/U6 snRNP 60 kDa protein, WD splicing factor Prp4, HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60,)
• NCBI Gene ID: 9128
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5T1M7
  UNIPROT ID#>>O43172
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pre-mRNA processing factor 4 interacts with:

• activator of basal transcription 1
  acyl-CoA binding domain containing 5
  Aly/REF export factor
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  ATP synthase membrane subunit f
  CD2 cytoplasmic tail binding protein 2
  cell division cycle 37, HSP90 cochaperone
  centrosomal AT-AC splicing factor
  centrosomal protein 250
  ceramide kinase
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  coiled-coil-helix-coiled-coil-helix domain containing 2
  COP9 signalosome subunit 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin dependent kinase 12
  DEAD-box helicase 23
  DEAH-box helicase 33
  DEAH-box helicase 37
  DGCR8 microprocessor complex subunit
  elongation factor Tu GTP binding domain containing 2
  ENAH actin regulator
  endoplasmic reticulum-golgi intermediate compartment 1
  epidermal growth factor receptor pathway substrate 15 like 1
  FKBP prolyl isomerase 15
  gephyrin
  G-patch domain and KOW motifs
  HEXIM P-TEFb complex subunit 1
  ILK associated serine/threonine phosphatase
  kinesin associated protein 3
  La ribonucleoprotein 7, transcriptional regulator
  LSM1 homolog, mRNA degradation associated
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM8 homolog, U6 small nuclear RNA associated
  lysine demethylase 5B
  methylphosphate capping enzyme
  methyltransferase like 18
  NEDD4 binding protein 2 like 2
  nitric oxide synthase 1 adaptor protein
  nuclear prelamin A recognition factor
  Obg like ATPase 1
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase 4
  Parkinsonism associated deglycase
  PAT1 homolog 1, processing body mRNA decay factor
  peptidylprolyl isomerase H
  pleckstrin homology domain containing A4
  polyglutamine binding protein 1
  POP4 homolog, ribonuclease P/MRP subunit
  prefoldin subunit 6
  pre-mRNA processing factor 19
  pre-mRNA processing factor 3
  pre-mRNA processing factor 3
  pre-mRNA processing factor 31
  pre-mRNA processing factor 4
  pre-mRNA processing factor 6
  pre-mRNA processing factor 8
  pre-mRNA processing factor 8
  prostaglandin reductase 2
  pyrin and HIN domain family member 1
  RAD18 E3 ubiquitin protein ligase
  RecQ like helicase 4
  ribosomal protein L26 like 1
  ring finger and CCCH-type domains 2
  ring finger protein 157
  RIO kinase 1
  RNA binding motif protein 42
  SAS-6 centriolar assembly protein
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  small nuclear ribonucleoprotein U5 subunit 200
  small nuclear ribonucleoprotein U5 subunit 40
  SNW domain containing 1
  spectrin repeat containing nuclear envelope protein 2
  spliceosome associated factor 3, U4/U6 recycling protein
  splicing factor 3a subunit 1
  splicing factor 3a subunit 3
  splicing factor 3b subunit 1
  splicing factor 3b subunit 3
  squamous cell carcinoma antigen recognized by T cells 1
  squamous cell carcinoma antigen recognized by T cells 3
  target of EGR1, exonuclease
  terminal uridylyl transferase 1, U6 snRNA-specific
  thioredoxin domain containing 5
  thioredoxin like 4A
  tripartite motif containing 28
  tropomodulin 3
  tubulin gamma complex associated protein 2
  tuftelin interacting protein 11
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 39
  WD repeat containing antisense to TP53
  WW domain binding protein 4
  zinc finger CCCH-type and G-patch domain containing

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.